EFFICACY AND PHARMACOKINETICS OF KANAMYCIN IN PSEUDOMONAS ELUORESCENS INFECTED CLARIAS LAZERA FISH | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 44, Issue 2, April 1996, Pages 443-451 PDF (4.32 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmjg.1996.376554 | ||
| Authors | ||
| AMER M.* 1; YONIS A.2; ABD EL-AZIZ S.2; NAGUIB M.2 | ||
| 1Department of Pharmacology, faculty of Vet. Medicine, Cairo Univ. | ||
| 2Department of Fish Diseases, Animal Health Research Institute, Dokki. | ||
| Abstract | ||
| Efficacy and pharmacokinetics of kanamycin were Studied in P. fluorescens infected Clarias lazera (Nile catfish). The clinical sings of P.fluorescens infection started after 12-24 hours post intraperitoneal inoculation. Kanamycin was injected in a single dose (20 mg/kg b.wt.) in the infected group and another apparently healthy control group. Recovery percent reached 73.33 in the infected fish group after 48 hours® post antibiotic injection Kanamycin was rapidly absorbed after intraperitoneal injection and reached its highest concentration 9.87+0.00059 and 9.20+0.85 µg/ml four hours post injection in normal and infected fish groups, respectively. Kanamycin was rapidly absorbed in infected fish ( a = 0.2726 + 0.002h"! and ty < & = 2.69 + 0.16 min.) than in normal fish a= 0.20420.009h"! and ty, a= 3.4420.14 min.). Kanamycin was rapidly excreted in infected fish with ty 5 B= 5.63+0.3764 hrs than in normal fish with tp 5 B= 7.55+1988 hrs. The interval between doses was short in infected fish 44.28 hrs than in normal fish 55.85hrs. | ||
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