ABD EL-ATY, A., GOUDAH, A., M., A., M., A., A., E., A., S. (1996). PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS. test, 44(2), 453-461. doi: 10.21608/vmjg.1996.376557
A ABD EL-ATY; A GOUDAH; ATEF M.; AMER M.; El- BANNA A.; SOLIMAN A.. "PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS". test, 44, 2, 1996, 453-461. doi: 10.21608/vmjg.1996.376557
ABD EL-ATY, A., GOUDAH, A., M., A., M., A., A., E., A., S. (1996). 'PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS', test, 44(2), pp. 453-461. doi: 10.21608/vmjg.1996.376557
ABD EL-ATY, A., GOUDAH, A., M., A., M., A., A., E., A., S. PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS. test, 1996; 44(2): 453-461. doi: 10.21608/vmjg.1996.376557

PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS

Veterinary Medical Journal (Giza)
Volume 44, Issue 2, April 1996, Pages 453-461    PDF (4.37 M)
DOI: 10.21608/vmjg.1996.376557
Authors
A ABD EL-ATY1; A GOUDAH1; ATEF M.* 2; AMER M.2; El- BANNA A.2; SOLIMAN A.2
1Department of Pharmacology, FACULTY OF Veterinary medicine ,Cairo University
2Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University
Abstract
The pharmacokinetic profile, tissue distribution and residual content of pipemidic acid were studied in normal and nephritic rats. The maximum serum concentration was reached after 1 hr. in both normal and nephritic rats following oral administration of 50 mg/kg b. wt. Lower serum concentrations were detected in nephritic rats at corresponding time intervals as compared with healthy ones. Following. The intravenous injection of pipemidic acid, the resulting curves were best fitted to follow two compartment open model. The drug was highly. distributed in all tested tissues and completely disappeared from all tissues after 9 and 15 days in healthy and nephritic rats following its oral administration in a dose of 50 mg/kg b. wt. twice daily for 5 successive days.
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