EFFECT OF AFLATOXICOSIS ON THE KINETIC BEHAVIOUR OF CEFTIOFUR IN CHICKENS | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 46, Issue 1, January 1998, Pages 17-27 PDF (3.25 M) | ||
| DOI: 10.21608/vmjg.1998.377231 | ||
| Authors | ||
| AZIZA M. M AMER* 1; EISHA M. M. FAHIM2; RAWIA K. IBRAHIM2 | ||
| 1Pharmacology Department, Faculty of Vet. Medicine, Cairo Unviersity | ||
| 2Biochemistry Department, Animal Health Research Institute, Dokki. | ||
| Abstract | ||
| The kinetic behaviour of ceftiofur sodium was studied in aflatoxin treated (for 30 days) and non-treated chickens following oral, intramuscular and intravenous administrations of 10 mg kg-1B. Wt. Aflatoxicosis resulted in a significant decrease In ceftiofur serum concentration in the treated rather than non-treated chickens following oral and intravenous administration. The kinetic behaviour showed that following intravenous injection, the elimination half life time t 0.5 (el) was significantly shorter in the treated (1.75 +0.03 h) than in non-treated chickens (4.23 + 0.05 h) following oral administration, the kinetic behaviour revealed long absorption half-life (t 0.5 (ab) ,62.74 ±1.59 min) in the treated than non-treated chicken (50.46± 5.07 min) ,with low Cmax 23.25 ±0.42 ug ml-1 at long tmax (3.05 ± 0.07 h) In treated than non treated chickens( Cmax 27.83 ± 1.28 at tmax 2.39 ± 0.07 h) | ||
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