Ferrite nanostructures as promising candidates for voltammetric monitoring of the tumor marker vanillylmandelic acid | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 4, April 2025, Pages 123-133 PDF (1.23 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2024.308170.10098 | ||
| Authors | ||
| hassan Hendawy1; Elmorsy A Khaled* 2 | ||
| 1Egyptian Drug Authority, Giza 12622, Egypt | ||
| 2Anal Chem. Lab, NRC | ||
| Abstract | ||
| The fabrication and electroanalytical futures of a novel disposable planner sensor integrated with zinc ferrite/multi-walled carbon nanotubes (ZnFR/MWCNTs) nanocomposite was introduced for selective quantification of the tumor marker vanillylmandelic acid (VMA) for early detection of neuroblastoma. The ZnFR/MWCNTs composite showed efficient electrocatalytic activity towards oxidation of VMA molecule with two distinct anodic peaks at 0.69 and 0.865 V following a diffusion-controlled reaction mechanism. Linear calibration graphs were illustrated covering the VMA concentration ranged from 0.11 to 2.74 µmol L-1 with a limit of detection value 0.03 µmol L-1 which is below the VMA concentration in the biological sample. The peak resolution between the VMA and those for homovanillic acid (HVA), uric acid (UA), and dopamine (DA) encourages the application of the disposable sensors for submicromolar assay of VMA in urine samples and fast diagnosis of neuroblastoma. The VMA oxidation mechanism was also presented based on theoretical molecular orbital studies. | ||
| Keywords | ||
| Vanillylmandelic acid; Submicromolar voltammetric assay; Zinc ferrite nanocomposite; Biological analysis; Oxidation mechanism; Neuroblastoma diagnosis | ||
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