ABCB1 C1236T/C3435T SNPs among Egyptian patients infected with Helicobacter pylori | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 04 September 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2024.308833.2123 | ||
| Authors | ||
| Mona M. Hassouna1; Aliaa Sabry S. Abdel Wahed2; Marwa A. Gouda* 3; Basma M Eltabakh4; Marwa A Tahoon5; Dina Sweed6; Heba Allah E Abdelrhman7; Ahmed S. Abdelgawad4 | ||
| 1Clinical Pathology Department, National Liver Institute, Menoufia University, Menoufia, Egypt | ||
| 2Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Menoufia, Egypt | ||
| 3Department of Clinical and Molecular Parasitology, National Liver Institute, Menoufia University, Menoufia, Egypt | ||
| 4Department of Clinical Pathology, National Liver Institute, Menoufia University, Menoufia, Egypt. | ||
| 5Department of Epidemiology and Preventive Medicine, National Liver Institute, Menoufia University, Shebin El Kom, Menoufia, Egypt | ||
| 6Department of Pathology, National Liver Institute, Menoufia University, Shebin El Kom, Menoufia, Egypt. | ||
| 7Department of Clinical and Chemical Pathology, Faculty of Medicine, Zagazig University. | ||
| Abstract | ||
| Background: Helicobacter pylori (H. pylori) is considered a significant cause of gastric diseases. It was linked to gastric carcinoma and lymphoma. Aim: The present study aimed to investigate the association between the genetic polymorphism of the ABCB1 gene (C1236T/C3435T) and the susceptibility to H. pylori infection and the response to therapy. Methods: 150 patients were enrolled. One hundred patients with positive H. pylori infection, and 50 negative control. Real-time Polymerase Chain Reaction (PCR) was used to detect C1236T (rs1128503) and C3435T (rs1045642) single nucleotide polymorphisms (SNPs). Results: The susceptibility of H. pylori infection was influenced by C1236T SNPs. The CC and CT genotypes showed a significant risky association with infection (OR = 8.3, 95%CI: 1.8 – 47.3) and (3.6, 95%CI: 1.11 – 12.4), respectively; p-value= 0.009). C allele was significantly associated with an increased risk of H. pylori infection (OR = 2.8, 95% CI: 1.4 – 5.9; p-value= 0.001). A significant association was found between the failure of treatment and the SNP C1236T (p < 0.01), especially the CT and CC genotypes (OR = 3.1, 95% CI: 1.3 – 7.1) and (5.1, 95%, CI: 1.4 – 18.2, respectively). Also, the C allele was significantly associated with an increased risk of treatment resistance (OR= 2.08, 95% CI: 1.07 – 3.7; p-value= 0.01). Conclusion: The frequencies of the C1236T [rs1128503] genotypes between cases and control were significantly different and was identified as a significant factor influencing the risk of H. pylori infection in addition to the outcomes of eradication regimen in Egyptian populations. | ||
| Keywords | ||
| ABCB1 C1236T/C3435T SNPs; Egyptians; H. pylori | ||
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