Curcumin Nanoparticles effects in protection and reducing Alzheimer's Disease induced by Aluminum Chloride | ||
| Biochemistry Letters | ||
| Volume 20, Issue 1, 2024, Pages 76-90 PDF (1.03 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/blj.2024.301016.1060 | ||
| Authors | ||
| Alaa Mohammed Alamin* 1; Shaimaa Ali abdelrahman2; Akaber Tarek Keshta3; Yasser Attia4 | ||
| 1Biocjhemistry deparyment ,faculty of science ,zagazig university | ||
| 2Medical Histology and cell biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||
| 3Biochemistry department, faculty of Science, zagzig University, Egypt | ||
| 4National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt | ||
| Abstract | ||
| Objective: The purpose of the current study was to use the curcumin nanoparticles in the protection and reduction of Alzheimer's disease (AD) induced by Aluminum chloride (AlCl3) in male rats. Material and Methods: 24 male albino rats were divided into four groups: group I (the negative control), group II (the diseased group), group III (the protective group), and group IV (the treated group). For each group, behavioral test was performed, biochemical evaluation of Malonaldehyde (MDA) levels and Catalase (CAT) activities, β-amyloid protein (APP) gene expression, immune-histochemical expression of p-Tau, and histological examination of the hippocampus were done. Results: Curcumin nanoparticles decreased the latency to escape box in the protective and therapeutic groups. Furthermore, there was reduction in the oxidative stress in MDA levels as well as downregulation of the relative expression of APP of brain tissue. It also ameliorated the histopathological alterations in the hippocampus with decreased immune expression of p-Tau protein. Conclusion: Nanocurcumin particles ameliorated the structural and functional alterations in the brain induced by AlCl3 so, it could be considered one of the promising therapeutic compounds for treating AD. | ||
| Keywords | ||
| inflammation; Phosphorylated tau protein; oxidative stress; Cognitive impairment Beta amyloid protein | ||
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