Field and Nodal Irradiation in Early Stage Hodgkin’s Lymphoma: A Single Institution Study | ||
| SECI Oncology Journal | ||
| Volume 12, Issue 3, July 2024, Pages 290-296 | ||
| Abstract | ||
| Background: With the introduction of Hodgkin lymphoma patients receiving combined modality therapy, extended field radiation techniques were replaced by involved field radiotherapy (IFRT). Recent research has demonstrated the safety of further field site reductions. By using the idea of involved node radiotherapy (INRT), the risk of radiation-induced toxicity can be decreased without compromising the effectiveness of treatment. The foundation of INRT is treating only the lymph nodes that were initially involved and omitting any adjacent uninvolved nodal areas. Patients and methods: 66 patients with early-stage Hodgkin's lymphoma were collected within the previous five years in SECI and were classified into two arms either IFRT or INRT after receiving chemotherapy according to disease stage. Out of those patients thirty eight received (IF) and twenty eight received (IN). Radiotherapy dose used for all patients was 20- 30 Gy. Patients were assessed for treatment toxicity and local recurrence. Results: Median follow up time of all patients was about 40 months. It was found that involved INRT was not inferior to IFRT. No difference in efficacy between both arms and also with comparable toxicity. Both groups had comparable characteristics, laboratory data, and response to chemotherapy. Relapse occurred in four patients (10.5%) in IFRT group and two patients (7.1%) in INRT group. Also, both groups had insignificant difference as regard overall survival 56.78 ± 2.40 vs. 56.78 ± 2.19 (months), of (IF) and (IN) respectively with p- value of 0.30. Both groups had comparable early toxicity and its grades, response and late toxicity (p> 0.05). Late complications as hypothyroidism developed in three patients of IFRT group and two patients of INRT group. Pulmonary fibrosis developed only in four (10.5%) patients of IFRT group. Conclusion: The main finding in this study is that (IN) is not inferior to (IF) as regards efficacy and at least same toxicity therefore (IN) radiotherapy can replace (IF). | ||
| Keywords | ||
| Hodgkin’s Lymphoma; Nodal Irradiation; Field irradiation | ||
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