Detection of Subclinical Right Ventricular Dysfunction in Patients with Hepatitis C Virus Infection by Speckle Tracking Echocardiographic Assessment | ||
| Suez Canal University Medical Journal | ||
| Article 1, Volume 27, Issue 4, April 2024, Pages 1-8 PDF (307.01 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2024.380310 | ||
| Authors | ||
| Islam Z. Mahmoud* ; Ahmed H. Abdel-Moneim; Hesham H. Ali; Enas A. Ismail | ||
| Department of Cardiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. | ||
| Abstract | ||
| Background: Hepatitis C virus (HCV) infection is associated with cardiac dysfunction, affecting patients’ morbidity and mortality. This study aimed at assessing whether myocardial deformation indices by two- (2D) and three-dimensional (3D) speckle tracking echocardiography can be used as an early imaging biomarker of right ventricular (RV) function affection in HCV patients even in early stages without significant hepatic cirrhosis. Subjects and Methods: 54 HCV patients were recently diagnosed by PCR and classified as Child Paugh A without previous cardiovascular events, and 54 matched healthy controls were enrolled. RV function was assessed using the transthoracic echocardiography conventional and advanced deformation assessment by speckle tracking including global longitudinal and segmental strain. Results: All conventional parameters resulted in the normal range without significant differences between HCV and controlsincluding RIMP, TAPSE, FAC, and S’ velocity (P value: 0.41, 0.11, 0.74, and 0.11, respectively). Only the apical RV free wall segment longitudinal strain by speckle tracking was more impaired than controls (-19.19 ± -7.23 vs. -21.64 ± -2.07, P value: <0.001). At the same time, the Global longitudinal strain (-24.2 ± -4.91% vs. -24.98 ± -2.61%, p = 0.171) was similar in both groups. Conclusion: Speckle tracking can detect subclinical RV dysfunction in HCV patients even with normal baseline conventional parameters. | ||
| Keywords | ||
| Hepatitis C Virus; Right ventricular dysfunction; RV Speckle tracking | ||
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