Evaluation of Serum Level of Histone Deacetylase 1 Enzyme in Patients with Acne Vulgaris | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 123, Volume 96, Issue 1, July 2024, Pages 3169-3173 PDF (523.58 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2024.380507 | ||
| Abstract | ||
| Background: Acne vulgaris (AV) is a highly prevalent skin inflammatory disorder. Histone modifications are common epigenetic processes, which happen secondary to environmental conditions. One of the many biological pathways' epigenetic regulation mechanisms is histone acetylation and deacetylation. Objective: To evaluate the serum levels of histone deacetylase 1 (HDAC1) enzyme in AV cases and to examine their correlation with AV severity. Patients and Methods: A case-control study was conducted on 90 participants: 45 patients with acne vulgaris and 45 healthy controls (HC). Global acne grading system (GAGS) was calculated. Then, serum HDAC1 level was measured by using ELISA. Results: Cases showed significantly higher HDAC1 level when compared to control group. HDAC1 among case group showed a significant gradual increase in mild, moderate, severe, and very severe grades. Moreover, positive significant correlation with the score of acne vulgaris was demonstrated (p < 0.001). Conclusion: Human histone deacetylases1 (HDAC1) appears to be dysregulated in cases with AV. This could suggest a possible therapeutic opportunity for HDAC inhibitors for AV management. | ||
| Keywords | ||
| Acne Vulgaris; Histone Deacetylase 1; Histone Acetyltransferases; Global Acne Grading System | ||
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