Mohammed, I., Nafea, M., Jawad, R., Abd, D., Aljoubory, H. (2024). Evaluation of the effect of green synthesis of Zinc oxide nanoparticles on Candida albicans. test, 10(3), 518-529. doi: 10.21608/jbaar.2024.380628
Inas Saad Mohammed; Mustafa Hatem Nafea; Raid Salih Jawad; Diyar Abdelkarim Abd; Hadeer Muthana Aljoubory. "Evaluation of the effect of green synthesis of Zinc oxide nanoparticles on Candida albicans". test, 10, 3, 2024, 518-529. doi: 10.21608/jbaar.2024.380628
Mohammed, I., Nafea, M., Jawad, R., Abd, D., Aljoubory, H. (2024). 'Evaluation of the effect of green synthesis of Zinc oxide nanoparticles on Candida albicans', test, 10(3), pp. 518-529. doi: 10.21608/jbaar.2024.380628
Mohammed, I., Nafea, M., Jawad, R., Abd, D., Aljoubory, H. Evaluation of the effect of green synthesis of Zinc oxide nanoparticles on Candida albicans. test, 2024; 10(3): 518-529. doi: 10.21608/jbaar.2024.380628

Evaluation of the effect of green synthesis of Zinc oxide nanoparticles on Candida albicans

Journal of Bioscience and Applied Research
Volume 10, Issue 3, September 2024, Pages 518-529    PDF (1.09 M)
Document Type: Original Article
DOI: 10.21608/jbaar.2024.380628
Authors
Inas Saad Mohammed1; Mustafa Hatem Nafea* 1; Raid Salih Jawad1; Diyar Abdelkarim Abd2; Hadeer Muthana Aljoubory3
1Department of Biomedical Engineering, University of Technology- Iraq.
2Nanotechnology and Advanced Materials Research Center, University of Technology- Iraq.
3Central library, University of Technology- Iraq.
Abstract
The application of metal oxide nanoparticles, particularly zinc oxide, in medicine is essential, especially due to their physical and chemical characteristics and their antifungal potential. By the biological method, the zinc oxide nanoparticles were synthesized. This study aimed to investigate the in vitro activity generated by zinc oxide nanoparticles using a biological technique against Candida albicans in leukemia patients. The zinc oxide nanoparticles underwent characterization using Fourier transform infrared spectroscopy and XRD. The ability of the synthesized nanoparticles to inhibit human Candida albicans isolated from leukemia patients could be achieved by the Sabouraud Dextrose Agar method and differentiated using CHROM candida agar, germ tube test, and API Candida albicans. The antifungal activity of zinc oxide was investigated against Candida albicans. After assessing its susceptibility to several types of fungal antibiotics, thirty-three samples of Candida albicans developed resistance to fungal activity. Candida albicans inhibition zone diameters were 11, 12, 12, and 10 mm at zinc oxide nanoparticle concentrations of 400, 200, 100, and 50 mg/ml, respectively, while no inhibition zones occurred at low values of 25 mg/ml.
Keywords
Biosynthesis, Candida albicans, Nanomedicine, Nanoparticles; Zinc oxide
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