Focus on Advancements in Amikacin Sulfate Delivery and Safety | ||
| Records of Pharmaceutical and Biomedical Sciences | ||
| Volume 8, Issue 3, 2024, Pages 132-143 PDF (1.08 M) | ||
| Document Type: Mini-reviews | ||
| DOI: 10.21608/rpbs.2024.308403.1312 | ||
| Authors | ||
| Shadeed Gad* 1; Mohamed Desoqi2; mohammed fawzy3; Mamdouh Ghourab4; Tamer H. Hassan5; Hossam elsawy6 | ||
| 1Faculty of Pharmacy - Suez Canal University | ||
| 2Pharmacy Department, The Armed Forces Medical Complex, Qobry El Qoba, Ministry of Defense, Egypt | ||
| 3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Egyptian Russian University, Cairo 11829, Egypt. | ||
| 4scu | ||
| 5Pharmaceutics & Industrial Pharmacy Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt. | ||
| 6Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt | ||
| Abstract | ||
| Aminoglycosides are a class of potent antibiotics widely used in the treatment of severe bacterial infections. However, their clinical efficacy is often limited by issues such as poor bioavailability, systemic toxicity, and the emergence of antibiotic resistance. To overcome these challenges, various drug delivery systems have been developed to enhance the therapeutic outcomes of aminoglycosides. This review article provides a comprehensive overview of the different drug delivery systems employed for aminoglycosides, with a specific focus on amikacin. The review discusses the rationale behind the use of drug delivery systems, the various types of delivery systems available, their advantages and limitations, and recent advancements in the field. The aim is to provide a detailed understanding of the current state-of-the-art drug delivery systems for aminoglycosides, particularly amikacin, and their potential in improving the clinical outcomes of aminoglycoside therapy. | ||
| Keywords | ||
| Aminoglycosides; amikacin; drug delivery systems; encapsulation; nanoparticles; liposomes; hydrogels | ||
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