AbouZaid, O., A.H, S., A.A., S., Z.M., F. (2018). Biochemical effect of leuprolide, cabergoline and some herbals on ameliorating polycystic ovaries syndrome. test, 35(1), 123-133. doi: 10.21608/bvmj.2018.38231
Omayma, A.R. AbouZaid; Samy, A.H; Samir, A.A.; Fatma, Z.M.. "Biochemical effect of leuprolide, cabergoline and some herbals on ameliorating polycystic ovaries syndrome". test, 35, 1, 2018, 123-133. doi: 10.21608/bvmj.2018.38231
AbouZaid, O., A.H, S., A.A., S., Z.M., F. (2018). 'Biochemical effect of leuprolide, cabergoline and some herbals on ameliorating polycystic ovaries syndrome', test, 35(1), pp. 123-133. doi: 10.21608/bvmj.2018.38231
AbouZaid, O., A.H, S., A.A., S., Z.M., F. Biochemical effect of leuprolide, cabergoline and some herbals on ameliorating polycystic ovaries syndrome. test, 2018; 35(1): 123-133. doi: 10.21608/bvmj.2018.38231

Biochemical effect of leuprolide, cabergoline and some herbals on ameliorating polycystic ovaries syndrome

Benha Veterinary Medical Journal
Article 13, Volume 35, Issue 1, September 2018, Pages 123-133    PDF (608 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2018.38231
Authors
Omayma, A.R. AbouZaid1; Samy, A.H1; Samir, A.A.2; Fatma, Z.M.1
1Department of Biochemistry, Faculty of Veterinary Medicine, Benha University
2Department of Animal Hygiene, Faculty of Veterinary Medicine, Benha University
Abstract
Polycystic ovary syndrome (PCOS) is a set of symptoms due to elevated androgens\in females. Its Signs include irregular or no menstrual periods, heavy periods, excess body and facial hair, acne, pelvic pain, difficulty getting pregnant, and patches of thick, darker, velvety skin. It could be a result from the combination of genetic and environmental factors. Many drugs used for treating this disease. Several hormones have been measured to evaluate PCOS (progesterone, Estradiol, Follicular Stimulating Hormone (FSH), Luteinizing hormone (LH), Total Testosterone, Anti-Mullerian Hormone (AMH), Thyroid Stimulating Hormone (TSH), Prolactin and histopathological studies. Groups were classified as follow: Group (1) Control, Group (2) Dehydroepiandrosterone (DHEA only), Group (3) (DHEA and flaxseed), Group (4) (DHEA and alfalfa), Group (5) (DHEA and Soya), Group (6) (DHEA and Cabergoline), and Group (7) (DHEA and Leuproline). Results: DHEA in a dose of (1mg/kg) induced PCOS and it was clear by significant elevation of (LH/ FSH ratio, total testosterone, AMH, TSH, Prolactin) and a significant decrease in progesterone and estradiol. Leuproline was the best choice to decrease the symptoms of PCOS followed by cabergoline and the least but still effective were the herbals (Soya, flaxseed, and alfalfa).  In conclusion, DHEA could be used for PCOS induction, Leuproline, cabergoline and phytoestrogen containing herbals could be used for treating PCOS symptoms.
Keywords
PCOs; DHEA; Leuproline; Cabergoline; Soya; alfalfa; Flaxseed
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