Histopathological and Biochemical Changes in Acute and Chronic toxicity of Strox; a psychoative substance in Egypt | ||
| Mansoura Journal of Forensic Medicine and Clinical Toxicology | ||
| Volume 32, Issue 2, July 2024, Pages 100-114 PDF (2.95 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjfmct.2024.298404.1080 | ||
| Authors | ||
| salma Ibrahim abd elkader1; Asmaa Abo Zeid2; Walaa Baher3; shimaa talaat* 4; Rania Hussien5 | ||
| 1Forensic Medicine & Clinical Toxicology Department, Faculty of Medicine, Ain Shams University | ||
| 2Histology and Cell Biology Department, Faculty of medicine, Ain Shams University, Cairo, Egypt. | ||
| 3Histology and Cell Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| 4Poison Control Center of Ain Shams University Hospitals ,Cairo ,Egypt | ||
| 5Forensic Medicine & Clinical Toxicology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| Abstract | ||
| Background: Strox is an Egyptian version of spic. It is a mixture of several substances sprayed on the plant to enhance its effect. This study aimed to assess the histopathological and biochemical effects of Strox after acute and chronic exposure by an experimental study. Methods: Eighty adult male Wistar rats were classified into four groups; negative and positive control groups, an acute toxicity group subdivided into 3 groups that received 1/3, 2/3, and LD50 respectively, and a chronic (dependence) group. The biochemical analysis included ALT, AST, BUN, creatinine, total CPK, CK-MB, and troponin in addition to histopathological examination of the cerebellum, heart, lung, liver, and kidney. Results: There was a significant increase in AST, ALT, total CPK, and CPK-MB in the dependence group. There was a great affection for hepatocytes in both acute and chronic groups up to the loss of hepatocytes. Cardiac muscles showed necrosis and fragmentation in both groups. The kidney showed renal tubular necrosis in both groups. Cerebellum showed distortion and a decrease in the number of stellate, basket, and Purkinje cells in both groups. The lung showed thickened alveolar septa with inflammatory cells and hemorrhage in all experimental groups. Conclusion: The study concluded that acute and chronic Strox toxicity induced profound histopathological changes in the heart, lung, liver, cerebellum, and kidney. These changes were further confirmed by the altered biochemical tests in the chronic group. | ||
| Keywords | ||
| Strox; Toxicity; Designer drugs; Synthetic cannabinoids | ||
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