Evaluation of Ki67 Predictive Role and its Discordance Between Pretherapy Biopsy and Post therapy Surgical Specimen in breast cancer patients receiving neoadjuvant chemotherapy | ||
| Ain Shams Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 October 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2023.211634.1125 | ||
| Authors | ||
| Yasmin El Sayed Mohamed Moussa* 1; Nivine Mahmoud Ahmed Gado2; Dalia Abd Elghany Elkhodary3; Diaa Eldin Moussa Shreef1 | ||
| 1Clinical oncology and Nuclear Medicine Department Faculty of Medicine, Ain shams University | ||
| 2Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Ain Shams University | ||
| 3Assistant Professor of Clinical Oncology and Nuclear Medicine. Faculty of Medicine, Ain Shams University | ||
| Abstract | ||
| Background: Neoadjuvant chemotherapy (NAC) in breast cancer patients provides an excellent model for evaluation of potential predictive factors. Both clinical complete response (cCR) and pathological complete response (pCR) achieved after NAC is a surrogate marker for a favorable prognosis. Factors capable of predicting response such as the proliferation marker Ki67 may help improve our understanding of the drug response and its effect on the prognosis and survival. Aim of the work: The aim of this study is to investigate the predictive value of the pretreatment Ki67 regard its ability to predict response to neoadjuvant chemotherapy and to investigate potential differences in proliferation scores between pretreatment core biopsies and post treatment final surgical samples in response to NAC. Patients & methods: A Retrospective Study conducted on sixty (60) eligible Female Patients with Non metastatic Breast Cancer patients receiving NAC. in the period from January 2015 till January 2020 at breast clinic unit at Ain-Shams University Hospitals Clinical Oncology department. All Patient characteristics, clinical and pathological data and immunohistochemistry analysis and treatment related data were thoroughly collected. Results: Pretreatment Ki-67 didn’t show any significant difference with both cCR and pCR. A significant decrease in Ki-67 expression from a median 25% in core biopsy prior to therapy to 12 % in surgical specimen after NAC in non-pCR patients Conclusion: Pretreatment K-i67 level Couldn’t play a predictive role in predicting both cCR and pCR. A significant change in Ki-67 expression was observed between core biopsy and surgical specimen after NAC in breast cancer patients | ||
| Keywords | ||
| Breast cancer; Tumor response; Molecular subtypes; Neoadjuvant chemotherapy; Ki67 | ||
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