Assessment of miRNA serological levels in oesophageal cancer patients from Southern Africa: insights into demographic-specific variation and potential predictor of disease severity | ||
| Fayoum University Medical Journal | ||
| Volume 14, Issue 1, October 2024, Pages 58-68 PDF (507.64 K) | ||
| Document Type: Full Length research Papers | ||
| DOI: 10.21608/fumj.2024.271300.1324 | ||
| Authors | ||
| Nolusindiso Bangani1; Gabriel Tchuente Kamsu* 2; Eugene Jamot Ndebia2 | ||
| 1Department of Human Biology, Walter Sisulu University, Nelson Mandela Drive, Mthatha, 5117, South Africa | ||
| 2Department of Human Biology; Faculty of Health Sciences, Walter Sisulu University, 5117-Mthatha, South Africa. | ||
| Abstract | ||
| Objective: The present study aimed to evaluate the demographic influences of serological miRNA levels in oesophageal cancer and it’s use as an indicator of the disease progression. Methods: The quantification of miRNA was examined in 51 newly diagnosed ESCC patients by means of quantitative ELISA kits utilised according to the manufacturer’s protocol. Demographic parameters were recorded and evaluated against the level of miRNA. Results : Our study showed that they were no significant relationship between the level of miRNAs and the studied parameters such as age, gender, alcohol, smoking, and oesophageal cancer severity. Conclusion: The study revealed that while age, gender, alcohol consumption, and smoking demonstrated varying associations with miRNA levels, none reached statistical significance, emphasizing the complexity of these relationships. Furthermore, the study found no significant correlation between miRNA levels and the progression of ESCC, challenging the notion of using miRNAs as reliable indicators of cancer severity in this specific population. | ||
| Keywords | ||
| Oesophageal Squamous Cell Carcinoma (ESCC); MicroRNA (miRNA) Dynamics; Cancer biomarkers; Demographic-specific variations; Diagnostic Potential | ||
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