THE PREVENTIVE EFFECT OF PROBIOTICS CONCERNING NEW DENTURE WEARERS IN ORAL CANDIDIASIS (CLINICAL TRIAL) | ||
| Alexandria Dental Journal | ||
| Article 37, Volume 50, Issue 1, April 2025, Pages 163-167 PDF (266.22 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/adjalexu.2024.258482.1458 | ||
| Authors | ||
| salma abdelaziz elsayes* 1; Mohamed Sherine EL-Attar2; Amany ahmed elhadary3; aliaa gamaleldin aboulela4; Ingy Hassan5 | ||
| 1prosthodontics, Alexandria University, Alexandria,Egypt | ||
| 2Prosthodontics Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. | ||
| 3Faculty of Oral and Dental Medicine, Future University, Cairo, Egypt. | ||
| 4Microbiology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt. | ||
| 5prosthodontics department faculty of dentistry Alexandria, Egypt | ||
| Abstract | ||
| Introduction: The most common therapeutic strategy for oral candidiasis is using antifungal agents, Unfortunately, the prolonged administration of antifungals has many adverse effects. There is an increasing demand for a potent antifungal agent against oral candidiasis (OC) with the least adverse effect and low recurrence rate. Objectives: To evaluate the preventive effect of a daily dose of commercial probiotics on the oral Candida spp. colonization in new denture wearers during probiotics administration and 4 weeks after the end of probiotics intake. Material and Methods: The current clinical trial included 48 new complete denture wearers with detectable levels of Candida but without clinical symptoms. Participants in the probiotics group received a daily dose of probiotics lozenges for eight weeks versus the placebo tablets taken by the participants in the placebo group. Microbiological mouth-rinse samples determined the Candida count at different time intervals: baseline, two weeks after denture delivery, after 4 and 8 weeks of intervention, and four weeks post-intervention follow-up. Results: Probiotics significantly reduced Candida count compared to placebo in the fourth week and subsequent follow-up periods. In the eighth week, they had the highest decrease (p < 0.0001). Conclusion: Probiotic lozenges were highly effective against fungal infections in new denture wearers, with short-term preventive effects even after intervention cessation. | ||
| Keywords | ||
| Keywords: Probiotics; Candidiasis; New denture wearers; Denture stomatitis | ||
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