SPANLASTICS: A Unique Formulation Strategy in The Delivery of Pharmaceuticals-Carbapenems as a Model. | ||
| Journal of Advanced Biomedical and Pharmaceutical Sciences | ||
| Article 1, Volume 7, Issue 4, October 2024, Pages 117-125 PDF (507.5 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/jabps.2024.298914.1221 | ||
| Authors | ||
| Shadwa Ahmed Mousa* 1; Milad Reda Qelliny2; Reham Ali Ibrahem3; Safy Hadiya4; Hatem A. Sarhan3; Fatma Mohammed Mady5 | ||
| 1Department of Pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt. Department of Pharmaceutics, Faculty of Pharmacy, Merit University Egypt (MUE), Sohag, Egypt. | ||
| 2Pharmaceutics Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt. | ||
| 3Department of Pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt. | ||
| 4Assuit International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assuit University, Assuit, 71515, Egypt. | ||
| 5Pharmaceutics Department, Faculty Of Pharmacy, Minia University, 61519 Minia, Egypt. | ||
| Abstract | ||
| Drug delivery systems based on nanotechnology have been significant in surpassing the challenges associated with traditional dose forms. A promising drug delivery vehicle is spanlastics, an elastic nanovesicle that can transport a variety of drug compounds. Spanlastics have shown an increasing amount of interest in various forms of administrative pathways. They may squeeze themselves through skin pores because they are elastic and malleable, making them ideal for transdermal delivery. Non-ionic surfactants or mixtures of surfactants make up spanlastics. Numerous studies have demonstrated how spanlastics greatly improve drug toxicity, drug bioavailability, and therapeutic efficacy. Our future goal is to evaluate the spanlastic-encapsulated carbapenem's antibacterial and anti-biofilm characteristics. Following the isolation of Staphylococcus epidermidis isolates and the assessment of their microbiological sensitivity, the plate microtiter test was employed to investigate their capacity to form biofilms. | ||
| Keywords | ||
| Nanoparticles; Spanlastics; Spans; Edge activators; Carbapenems | ||
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