Euphol: chemical and biological aspects: A review | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 17 October 2024 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2024.322067.10466 | ||
| Authors | ||
| Aya Fadle Shaban* 1; Mostafa A Abd El Kawy2; Ahmed Ragab Hamed3; Abeer Salama4; Amira kamal El motayam5 | ||
| 1Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. | ||
| 2Professor of Pharmacognosy, Faculty of Pharmacy Cairo University | ||
| 3Chemistry of Medicinal Plants Department, Pharmaceutical and Drug Industries Research Division. | ||
| 4cPharmacology Department, National Research Centre, Dokki, Giza, Egypt. | ||
| 5Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street | ||
| Abstract | ||
| The growing interest in herbal medicine as a potential source for drug development is being increasingly supported, particularly for addressing challenging therapeutic areas such as anti-inflammatory treatment, cancer, immunomodulatory effects, combating antimicrobial resistance, managing cardiovascular diseases, and tackling multiple sclerosis. Cancer stands as a leading cause of mortality globally. Harnessing the potent bio actives from nature presents a promising avenue in the fight against cancer. Euphol is a widely occurring tetracyclic triterpenoid found in various plants. It exhibits notable antitumoral properties, offering a potential alternative for cancer therapy. Euphol exhibits not only antitumoral potential but also antiviral activity. Additionally, Euphol demonstrates anti-inflammatory properties by inhibiting the activation of nuclear factor-kappa B (NF-κB), thereby mitigating colitis in mice. Furthermore, it inhibits the inflammatory response triggered by 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of protein kinase C in mouse skin. The natural sources of euphol triterpenoids have been explored, encompassing various plant families such as Euphorbiaceae, Clusiaceae, Cucurbitaceae, Theaceae and Guttiferae. This review aims to consolidate natural origins, biosynthesis, chemical synthesis, physicochemical properties, spectroscopic data and documented pharmacological activities of euphol. It delves into the potential beneficial effects of this bioactive triterpene and examines strategies to augment its pharmacological significance. | ||
| Keywords | ||
| Euphol; Terpenes; Tetracyclic triterpenes; Anti-inflammatory; Cytotoxic; Antibacterial; Antiviral | ||
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