Antibiotic Resistance genes dynamics and operation performance of AnMBRs under Amoxicillin/Flucloxacillin Exposure | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 21 October 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2024.307488.10086 | ||
| Authors | ||
| Mahmoud Saleh* 1; Ahmed Kamal2; Amany Tarek2; Safwat M. Safwat2; Abdelsalam Elawwad2 | ||
| 1Faculty of Science, Cairo University | ||
| 2Sanitary and Environmental Engineering Division, Public Works Department, Faculty of Engineering, Cairo University, Giza 12613, Egypt | ||
| Abstract | ||
| Anaerobic membrane bioreactors (AnMBRs) offer a promising solution for wastewater treatment, combining anaerobic digestion with membrane filtration to efficiently remove pollutants and mitigate the spread of antibiotic resistance genes (ARGs). The impact of antibiotic mixtures on AnMBR performance and ARG profiles remains crucial to investigate due to their prevalence in various environments. This study examined the effects of an amoxicillin and flucloxacillin mixture on key operational parameters in an AnMBR system. The AnMBR demonstrated resilience to the antibiotic mixture, maintaining a high average chemical oxygen demand (COD) removal efficiency (91 ± 4.5%) and stable biogas production (713 ± 150 L/d) even at elevated antibiotic concentrations (250 μg/L). However, antibiotic presence significantly influenced ARG profiles within the biomass and effluent, highlighting the complex interplay between antibiotic exposure and resistance gene dynamics. These findings emphasize the importance of understanding and optimizing AnMBR performance under antibiotic pressure to mitigate the spread of antibiotic resistance while ensuring effective wastewater treatment and resource recovery. | ||
| Keywords | ||
| Antibiotic resistance genes (ARGs); Anaerobic membrane bioreactors (AnMBRs); Wastewater treatment; Amoxicillin; Flucloxacillin; Antibiotic mixture | ||
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