Elroby, F., Ghaleb, S., Abdelsattar, H., Nagdi, G., Ahmad, M. (2024). The role of new potential biomarker for medicolegal aging of wounds. test, 5(4), 30-43. doi: 10.21608/ejmr.2024.262954.1528
Fadwa Aly Elroby; Sherein S Ghaleb; Hossam A Abdelsattar; Gehad Ali Nagdi; Manar A Ahmad. "The role of new potential biomarker for medicolegal aging of wounds". test, 5, 4, 2024, 30-43. doi: 10.21608/ejmr.2024.262954.1528
Elroby, F., Ghaleb, S., Abdelsattar, H., Nagdi, G., Ahmad, M. (2024). 'The role of new potential biomarker for medicolegal aging of wounds', test, 5(4), pp. 30-43. doi: 10.21608/ejmr.2024.262954.1528
Elroby, F., Ghaleb, S., Abdelsattar, H., Nagdi, G., Ahmad, M. The role of new potential biomarker for medicolegal aging of wounds. test, 2024; 5(4): 30-43. doi: 10.21608/ejmr.2024.262954.1528

The role of new potential biomarker for medicolegal aging of wounds

Egyptian Journal of Medical Research
Volume 5, Issue 4, October 2024, Pages 30-43    PDF (967.76 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.262954.1528
Authors
Fadwa Aly Elroby1; Sherein S Ghaleb1; Hossam A Abdelsattar2; Gehad Ali Nagdi* 1; Manar A Ahmad1
1Forensic medicine and clinical toxicology department, Faculty of medicine, Beni-Suef University, Beni-Suef , Egypt
2orthopedic surgery department, Faculty of medicine, Beni-suef University, Beni-suef
Abstract
Background: Estimating the age of a wound is crucial in the realm of forensic medicine. Determining the age and liveliness of a wound is essential for the appropriate handling of legal procedures. Objective: to evaluate the myostatin marker's usefulness in determining the age of medicolegal wounds. Methods: This cross-sectional investigation on the ante-mortem aging of surgically non-complicated wounds was conducted at the general and orthopedic surgery departments of Beni Suef University Hospital. 56 participants were divided evenly into two equal groups: Group B involved muscle injuries while Group A involved bone injuries. Each participant had blood drawn nine times following surgery: before and after zero (pre-operative), twenty-four hours, thirty-six hours, forty-eight hours, seventy-two hours, eighty-four hours, ninety-six hours, ninety-six hours, and one hundred and sixty hours (post-operative).  Results: Over the course of the five days, there were notable (P < 0.001) increases in myostatin levels, peaking 36 hours after the wound (3.73±0.42) as opposed to the bone injury group's zero time (2.07±0.76). Additionally, across the course of the five days, there were notable (P < 0.001) increases, with the muscle injury group's peak being reached 24 hours after the wounding (1.94±0.71) as opposed to the zero time (1.45±0.40). Conclusion: myostatin can be used to assess medicolegal wound age in bone and muscle injuries.
Keywords
Wound aging; Myostatin; Bone; Muscle
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