Changes in Albumin Level and Cachexia Parameters Over Time and Their Effect on Survival in Patients Who Received Chemotherapy | ||
| SECI Oncology Journal | ||
| Article 2, Volume 12, Issue 4, October 2024, Pages 332-343 | ||
| Abstract | ||
| Background: Cachexia is an irreversible multifactorial process. One of the most important indicators of nutritional status and a prognostic biomarker in cancer cachectic patients is serum albumin level, its reduction is associated with poor prognosis, we aimed to see effect of improvement over time in albumin on survival and the most independent factors for survival with the contributions of different clinic pathologic parameters to different cachexia parameters. Methods: a prospective observational single center study. 125 patients were enrolled after their diagnosis as cachectic patients. We collected demographic data, type of nutritional support, anthropometric measures and laboratory data are collected every 3 months for 1 year. Results: There was significant improvement of total protein and albumin and no significant improvement of body mass index across different time points of measurements despite increasing the percentages of patients attaining normal BMI. Surviving patients completing one year expressed significant improvement of oral intake. The mean OS was 6.4 months, and the median OS was 5 months. OS was positively correlated with serum albumin level. Only age, BMI, NLR, and PLR had significant effect on OS. Conclusion: Improvement of albumin with progression of time in patients who received their anticancer treatment had significant positive effect on overall survival of cancer cachectic patients. | ||
| Keywords | ||
| cachexia; albumin; nutrition | ||
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