Ahmed, M., Taha, A., Mahmoud, T., Ibrahim, R., Abdalla, N., Abdelsattar, A. (2024). Evaluation of Serum Soluble Transferrin Receptors in Detection of Iron Deficiency Anemia in Chronic Kidney Disease Patients on Hemodialysis. test, 5(4), 152-164. doi: 10.21608/ejmr.2024.305355.1643
Mohamed Ragab Ahmed; Asmaa Taha; Tamer M Mahmoud; Raghda E Ibrahim; Nilly Helmy Abdalla; Ahmed S Abdelsattar. "Evaluation of Serum Soluble Transferrin Receptors in Detection of Iron Deficiency Anemia in Chronic Kidney Disease Patients on Hemodialysis". test, 5, 4, 2024, 152-164. doi: 10.21608/ejmr.2024.305355.1643
Ahmed, M., Taha, A., Mahmoud, T., Ibrahim, R., Abdalla, N., Abdelsattar, A. (2024). 'Evaluation of Serum Soluble Transferrin Receptors in Detection of Iron Deficiency Anemia in Chronic Kidney Disease Patients on Hemodialysis', test, 5(4), pp. 152-164. doi: 10.21608/ejmr.2024.305355.1643
Ahmed, M., Taha, A., Mahmoud, T., Ibrahim, R., Abdalla, N., Abdelsattar, A. Evaluation of Serum Soluble Transferrin Receptors in Detection of Iron Deficiency Anemia in Chronic Kidney Disease Patients on Hemodialysis. test, 2024; 5(4): 152-164. doi: 10.21608/ejmr.2024.305355.1643

Evaluation of Serum Soluble Transferrin Receptors in Detection of Iron Deficiency Anemia in Chronic Kidney Disease Patients on Hemodialysis

Egyptian Journal of Medical Research
Volume 5, Issue 4, October 2024, Pages 152-164    PDF (937.66 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.305355.1643
Authors
Mohamed Ragab Ahmed1; Asmaa Taha* 1; Tamer M Mahmoud1; Raghda E Ibrahim2; Nilly Helmy Abdalla3; Ahmed S Abdelsattar3
1Department of internal medicine, faculty of medicine, Beni- Suef University
2Department of Clinical and Chemical Pathology, faculty of medicine, Beni- Suef University
3Department of Internal Medicine, Faculty of Medicine, Beni-Suef University
Abstract
Background: A increased risk of morbidity and death is associated with anemia, which is a well-known complication of chronic kidney disease (CKD), particularly in patients with end-stage renal disease who need frequent hemodialysis. Anemia strikes between 49% and 55% of CKD patients, and it becomes more common as the illness progresses. One of the most important signs of iron deficiency in the population-based survey is anemia. Objective: In hemodialysis-dependent patients with chronic renal disease, we evaluated the accuracy of serum soluble transferrin receptors for the diagnosis of iron deficiency anemia. Subjects and methods: we recruited 90 patients of both sexes with end-stage renal disease, ranging in age from 20 to 60 years. A full blood tests, including those for iron, ferritin, total iron binding capacity, saturation with transferrin, and soluble transferrin receptor, were performed on each patient. The data was analyzed using the Pearson correlation and the independent sample t test. It was considered significant when the P value was less than 0.05. Results: The results of our research showed that mean SsTFR level was (55.14±34.2), ranged between 0.3 and 125.9,there was no statistical significant correlation with p-value >0.05 between SsTFR level and all other iron profile tests (hemoglobin, serum iron, TIBC, ferritin, and transferrin Saturation) and there was no a statistical significant higher level SsTFR with p-value 0.05 in cases on dialysis for more than 6 months, and not treated with Erythropoietin and there was  also no statistical significance difference in SsTFR level as regards level of ferritin, or T. saturation.. Conclusion: We conclude that serum soluble transferrin receptors is insignificant in detection of iron deficincy anemia in our CKD patients on hemodialysis.
Keywords
SsTFR; CKD; iron deficiency anemia; hemodialysis
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