Effect Of Zinc Oxide and Selenium Nanoparticles on Milk Production Efficiency and Related Gene Expression in Egyptian Baladi Goats | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 5, May 2025, Pages 445-454 PDF (1023.21 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2024.320064.10421 | ||
| Authors | ||
| Hayam Mansour* 1; Ahmed A Aboamer2; Rania Agamy3; Shimaa M Ali4; Mahmoud Y Mohamed4; Mahmoud E Abd El-Aziz5; Ahmed M Darwish6; Wagdy K.B. Khalil1; Ibrahim M. Farag7 | ||
| 1Department of Cell Biology, Biotechnology research institute, National Research Centre, Giza, Egypt. | ||
| 2Dairy science department, National Research center, Dokki, Giza, Egypt | ||
| 3Animal production department, faculty of agriculture, Cairo university, Egypt | ||
| 4Animal production institute, agriculture research center, NC 12611, Dokki, Giza, Egypt | ||
| 5Polymers and Pigments Department, National Research Centre, Dokki, Giza, , Egypt | ||
| 6Cell Biology Department, Biotechnology Research Institute, National Research Centre, Dokki, Giza, Egypt | ||
| 7Department of Cell Biology, Biotechnology Research Institute, National Research Centre, Giza, Egypt. | ||
| Abstract | ||
| This study assessed the impact of oral administration of zinc oxide (ZnO) and selenium (Se) nanoparticles on milk production and gene expression in Baladi goats. Twenty-two pregnant females, 30 days before parturition, were divided into five groups: Group 1 (n=4) served as control; Groups 2 and 3 (n=4 each) received 150 mg ZnO and 0.3 mg of Se in microparticle (MP) forms, respectively; Groups 4 and 5 (n=5 each) received 15 mg ZnO and 0.03 mg Se in nanoparticle (NP) forms, respectively. Milk yield, composition, and gene expression related to milk production were analyzed. Results indicated a significant increase (P<0.001) in dry matter intake in the ZnO-NPs and Se-NPs groups, with an improved feed conversion ratio. Daily and overall milk yield, as well as fat-corrected milk yield, were highest in the NPs groups, particularly ZnO-NPs. Milk composition remained unchanged. Gene expression analysis showed significant upregulation of POU1F1, IGF-1, PPARγ, CSN2, and FASN in the NPs groups compared to the MPs and control groups, with the highest expression levels observed in the Se-NPs group. These findings suggest that ZnO-NPs and Se-NPs enhance milk production efficiency and upregulate key genes involved in milk yield in Baladi goats. | ||
| Keywords | ||
| Zinc oxide nanoparticles; Selenium nanoparticles; Milk yield; Milk composition; Gene expression; Baladi goats; RT-PCR | ||
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