Screening of nephropathic changes in pregnant diabetic women and their management with calcium channel blockers | ||
| Journal of Recent Advances in Medicine | ||
| Volume 5, Issue 2, July 2024, Pages 128-134 PDF (1.46 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jram.2024.302145.1253 | ||
| Authors | ||
| Asmaa AA. Abd El Aal* 1; Diaa MM. Fakhr2; Nagwa A. Mohamed2 | ||
| 1Obstetrics and Gynecology Department, Qeft Teaching Hospital, Qena, Egypt. | ||
| 2Obstetrics and Gynecology, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt. | ||
| Abstract | ||
| Background: Endothelial brokenness and dysregulation of vascular homeostasis are related with diabetic nephropathy (DN). Microalbuminuria (MAU) is a notable indicator of DN in Diabetes Mellitus (DM). Non-dihydropyridine Calcium channel blockers (CCBs) are utilized to diminish proteinuria related with nephropathy in DM patients. Objective: to detect the early nephropathic changes in diabetic pregnant women and identify the effect of non-dihydropyridine calcium channel blockers, on these changes. Methodology: Between May 2020 and March 2022, a randomized controlled clinical trial study was conducted at Al-Zahraa University Hospital. Laboratory tests included a complete blood count, fasting blood sugar, and kidney function test (urea, creatinine, Albumin Creatinine Ratio, and urine analysis for MAU) for pregnant women with diabetes mellitus and early DN. For a month, verapamil was taken orally at 80 mg per day. Results: In patients who have been taking non-dihydropyridine Calcium channel blockers there was a critical decrease in microalbuminuria in contrast with benchmark microalbuminuria, however in the control, no huge change was seen in follow-up microalbuminuria. Conclusions: after non-dihydropyridine Calcium channel blockers utilization, there was a critical decrease in the degree of albuminuria in contrast with the pre-treatment evaluation. | ||
| Keywords | ||
| Diabetic nephropathy; Diabetes Mellitus; Microalbuminuria; calcium channel blockers | ||
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