Abdelrahman, A., Ahmed, I., salem, R., Diab, Z. (2017). Hemodynamic and analgesiceffects of dexmedetomidine in patients undergoing major abdominal surgeries. test, 21(2), 45-55. doi: 10.21608/smj.2017.39248
Abdelrahman Hassan Abdelrahman; Islam Ahmed; Raffat ahmed salem; Zienab Diab. "Hemodynamic and analgesiceffects of dexmedetomidine in patients undergoing major abdominal surgeries". test, 21, 2, 2017, 45-55. doi: 10.21608/smj.2017.39248
Abdelrahman, A., Ahmed, I., salem, R., Diab, Z. (2017). 'Hemodynamic and analgesiceffects of dexmedetomidine in patients undergoing major abdominal surgeries', test, 21(2), pp. 45-55. doi: 10.21608/smj.2017.39248
Abdelrahman, A., Ahmed, I., salem, R., Diab, Z. Hemodynamic and analgesiceffects of dexmedetomidine in patients undergoing major abdominal surgeries. test, 2017; 21(2): 45-55. doi: 10.21608/smj.2017.39248

Hemodynamic and analgesiceffects of dexmedetomidine in patients undergoing major abdominal surgeries

Sohag Medical Journal
Article 6, Volume 21, Issue 2, July 2017, Pages 45-55    PDF (300.11 K)
Document Type: Original Article
DOI: 10.21608/smj.2017.39248
Authors
Abdelrahman Hassan Abdelrahman1; Islam Ahmed1; Raffat ahmed salem2; Zienab Diab
1Department, of Anesthesia & Intensive Care, Fuculty of Medicine, Sohag University.
2Department of, of Anesthesia & Intensive Care fuclty of Medicine, Sohag University.
Abstract
Background:Dexmedetomidine, a highly selective α2-adrenoceptor agonist, is widely used in clinical anaesthesia, and intensive care unit. The aim of this study is to evaluate the hemodynamic and analgesic effects of dexmedetomidine in major abdominal surgeries.
Patients and methods: 40 patients for radical cystectomy in the age range of 40 – 65 years participated in this prospective, randomized, double blinded, placebo controlled clinical study. Patients were randomly assigned to receive either Dexmeditomidine (Dex group) or normal saline (0.9%) (Control group).patients hemodynamics, Recovery profile, and Pain intensity were evaluated.
Results Intraoperative mean arterial pressure and heart rate were significantly lower but stable in Dex group. Patients in Dex group had lower VAS scores.
Conclusion:Dexmedetomidine is effective in attenuating hemodynamic response to surgical stimulation. Patients in Dex group experienced less postoperative pain.
Supplementary Files
References
  1. Abel Rahman, N. I., Fouad E. A., Ahmed, A., Youness, A. R. Efficacy of different dexmedetomidine regimens in producing controlled hypotensive anesthesia during functional endoscopic sinus surgery. Egyptian Journal of Anaesthesia 2014, 30, 339-345.
  2. Arain  S. R. and Ebert, T. J. The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation. AnesthAnalg 2002, 95, 461-6, table of contents.
  3. Fan, W, Yang, H, Sun, Y, Zhang, J, Li, G, Zheng, Y, and Liu, Y, Comparison of the pro-postoperative analgesia of intraoperative dexmedetomidine with and without loading dose following general anesthesia: A prospective, randomized, controlled clinical trial. Medicine (Baltimore), 2017. 96(7): p. e6106.
  4. Ge, DJ, Qi, B, Tang, G, and Li, JY, Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Colectomy: A CONSORT-Prospective, Randomized, Controlled Clinical Trial. Medicine (Baltimore), 2015. 94(43): p. e1727.
  5. George, RB, McKeen, DM, Andreou, P, and Habib, AS, A randomized placebo-controlled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy. Can J Anaesth, 2014. 61(6): p. 551-7.
  6. Herroeder, S., Pecher, S., Schonherr, M., Kaulitz. Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg 2007, 246, 192-200.
  7. Homburger JA, Meiler SE. Anesthesia drugs, immunity, and long- erm outcome. CurrOpinAnaesthesiol. 2006; 19:423–8.
  8. Hwang W, Lee J, Park J, Joo J. Dexmedetomidine versus remifentanil in postoperative pain control after spinal surgery: a randomized controlled study. BMC Anesthesiol. 2015 Feb 24; 15:21.
  9. Jaakola, M. L., Kanto, J., Kallio, A., Scheinin. Dexmedetomidine reduces intraocular pressure, intubation responses and anaesthetic requirements in patients undergoing ophthalmic surgery. Br J Anaesth 1992, 68, 570-5.
  10. JessenLundorf, L, KorveniusNedergaard, H, and Moller, AM, Perioperative dexmedetomidine for acute pain after abdominal surgery in adults. Cochrane Database Syst Rev, 2016. 2: p. Cd010358.
  11. Kang, S. H. et al. Effects of dexmedetomidine on inflammatory responses in patients undergoing laparoscopic cholecystectomy. ActaAnaesthesiol Scand. 57, 480–7 (2013).
  12. Lee, J, Park, J, JOO, J. Dexmedetomidine versus remifentanil in postoperative pain control after spinal surgery: a randomized controlled study. BMC Anesthesiol 2015, 15, 21.
  13. Manne, GR, Upadhyay, MR, and Swadia, V, Effects of low dose dexmedetomidine infusion on haemodynamic stress response, sedation and post-operative analgesia requirement in patients undergoing laparoscopic cholecystectomy. Indian J Anaesth, 2014. 58(6): p. 726-31.
  14. Movafegh, A, Shoeibi, G, Ansari, M, Sadeghi, M, Azimaraghi, O, and Aghajani, Y, Naloxone infusion and post-hysterectomy morphine consumption: a double-blind, placebo-controlled study.ActaAnaesthesiolScand, 2012. 56(10): p. 1241-9.
  15. Nelson, B. A. Laura E., Lu, M. , Guo, M., Saper, D. The α2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects. Anesthesiology 2003, 98, 428-436.
  16. O'Riain, S, Buggy, D, Kerin, M, Watson, R. Inhibition of the stress response to breast cancer surgery by regional anesthesia and analgesia does not affect vascular endothelial growth factor and prostaglandin E2. AnesthAnalg 2005, 100, 244-9.
  17. Ozcan, A., Ozcan, N., Yalcin, F. &Bascar, H. Comparison of the effects of fentanyl, remifentanil, and dexmedetomidine on neuromuscular blockade. J Anesth 2012, 26, 196-9.
  18. Tang, C, Huang, X, Kang, F, Chai, X, Wang, S, Yin, G, Wang, H, and Li, J, Intranasal Dexmedetomidine on Stress Hormones, Inflammatory Markers, and Postoperative Analgesia after Functional Endoscopic Sinus Surgery. Mediators Inflamm, 2015. 2015: p. 939431.
  19. Tasdogan M, Memis D, Sut N, Yuksel M. Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. J ClinAnesth. 2009; 21:394–400.
  20. Xianbao, L.; Hong, Z.; Xu, Z.; Chunfang, Z.; Dunjin, C. Dexmedetomidine reduced cytokine release during postpartum bleeding-induced multiple organ dysfunction syndrome in rats. Mediat. Inflamm. 2013, 2013, 627831.
  21. Yacout, A., Osman, H, Abdeldaem, M, Hammouda, S. Effect of intravenous dexmedetomidine infusion on some proinflammatory cytokines, stress hormones and recovery profile in major abdominal surgery. Alexandria Journal of Medicine 2012,
Statistics
Article View: 196
PDF Download: 251