Abuzied, T., Morgan, D., Abdelkreem, R., Abdelhalim, S. (2024). New Aspects in Pathogenesis of Primary Immune Thrombocytopenia In Pediatric Patients. test, 5(4), 221-235. doi: 10.21608/ejmr.2024.309094.1659
Taghreed Ahmed Abuzied; Dalia Saber Morgan; Rehab Muhamad Abdelkreem; Sahar Salah Abdelhalim. "New Aspects in Pathogenesis of Primary Immune Thrombocytopenia In Pediatric Patients". test, 5, 4, 2024, 221-235. doi: 10.21608/ejmr.2024.309094.1659
Abuzied, T., Morgan, D., Abdelkreem, R., Abdelhalim, S. (2024). 'New Aspects in Pathogenesis of Primary Immune Thrombocytopenia In Pediatric Patients', test, 5(4), pp. 221-235. doi: 10.21608/ejmr.2024.309094.1659
Abuzied, T., Morgan, D., Abdelkreem, R., Abdelhalim, S. New Aspects in Pathogenesis of Primary Immune Thrombocytopenia In Pediatric Patients. test, 2024; 5(4): 221-235. doi: 10.21608/ejmr.2024.309094.1659

New Aspects in Pathogenesis of Primary Immune Thrombocytopenia In Pediatric Patients

Egyptian Journal of Medical Research
Volume 5, Issue 4, October 2024, Pages 221-235    PDF (717.69 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.309094.1659
Authors
Taghreed Ahmed Abuzied* 1; Dalia Saber Morgan2; Rehab Muhamad Abdelkreem3; Sahar Salah Abdelhalim1
1Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
2Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef,Egypt.
3Clinical pathology department, Faculty of Medicine, Beni-Suef University, Egypt.
Abstract
Background: Immune thrombocytopenia is an autoimmune condition marked by a reduced number of platelets in the blood, which can be caused by either a breakdown of platelets inside the blood vessels or the abnormal synthesis of platelets in the bone marrow. although autoantibodies have been shown as the principal factor in the pathogenesis of immune thrombocytopenia, also cellular immune modulation has been recognized to have a vital role in the pathophysiology of ITP. Aim of the Work: the pathogenesis of primary immune thrombocytopenia in pediatric patients. Patients and Methods: A Case-Control, analytical research that has been performed over one year after the approval of the research ethics committee on 70 participants (twenty-four) men & (forty-six) females with ages varying from (2 years) to (13 years) & an average age of (6.28±2.86) years old, Cases underwent history taking & clinical investigation. Laboratory investigations included CBC, DPC, ESR, bleeding time, C- C-reactive protein, and single nucleotide polymorphism. Conclusion: consanguinity was associated with ITP.  It is widely recognized that the pathogenesis of immune thrombocytopenia is significantly influenced by environmental & genetic factors. The susceptibility of cases to immune thrombocytopenia is influenced by single-nucleotide polymorphisms (SNP) of inflammatory cytokine loci, including IL-10, IL-17F, TNF-β, TNF-α, IL-6, TGF-β1, INF-γ, & IL0-1A. Additionally, various autoimmune disorders are related to genetic variants of inflammation-related genes, involving  CD226, CD24,IL-2, FCRL3,  ITGAM, IRF5,CARD8, NLRP3,  SH2B3, PTPN22, TNFAIP3, TRAF1, & STAT4.           
Keywords
Immune Thrombocytopenic Purpura; bleeding; platelets
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