Prognostic Significance of Lymph-Node Ratio in Patients with Oral Squamous Cell Carcinoma | ||
| SECI Oncology Journal | ||
| Article 7, Volume 12, Issue 4, October 2024, Pages 378-387 | ||
| Abstract | ||
| Background: The aim of this study was to assess the prognostic significance of lymph node ratio (LNR) in patients diagnosed with oral squamous cell carcinoma (OSCC). Methods: This retrospective study included 82 patients with oral squamous cell carcinoma (OSCC) with positive nodal disease, who underwent surgical treatment for primary OSCC & received adjuvant treatment at the Clinical Oncology & Nuclear Medicine Department, Mansoura University Hospital, between January 2010 and June 2022. Patients' data were analyzed using log- rank statistic, univariate and multivariate data analyzes, and p values, for prediction of significance of lymph node ratio on overall and disease-free survival. Results: Prognostic thresholds were determined at a cutoff value of 0.073% for LNR. LNR < 0.073 was a significant predictor of longer OS. LNR <0.073 was a significant predictor of longer OS (72 months vs 14 months in those with LNR < 0.073), while patients with LNR whether < 0.073 or ≥ 0.073 demonstrated nearly the same median DFS (39 months vs 37 months, respectively). Multivariate analysis revealed that lymph node ratio (LNR), neck dissection, lymphovascular embolization (LVE), perineural invasion and adjuvant treatment were confirmed as independent prognostic factors for OS. Conclusion: Lymph node ratio (LNR) is a prognostic factor for survival in patients with oral squamous cell carcinoma (OSCC), who underwent surgical treatment for primary OSCC. | ||
| Keywords | ||
| lymph node ratio; oral squamous cell carcinoma, staging; survival analysis | ||
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