Relationship between Thyroid Functions and Estimated Glomerular Filtration Rate in Patients with Chronic Kidney Disease | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 119, Volume 97, Issue 1, October 2024, Pages 4232-4239 PDF (551.2 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2024.394609 | ||
| Abstract | ||
| Background: Chronic kidney disease(CKD) stands for a gradual decline in renal function occurring over months or years. Thyroid hormones exert specific influences on cellular differentiation as well as growth. The interaction between the thyroid and kidney in their respective functions has been recognized for several years. Thyroid dysfunction influences renal development as well as physiology, while kidney diseases may lead to thyroid dysfunction. Objective: Our research was carried out to assess the correlation between thyroid function and estimated GFR among CKD cases. Patients and methods: Our team designed a cross-sectional study including 117 cases developing CKD of varying etiology but not undergoing hemodialysis. Participants underwent a categorization based on GFR, measured by the " CKD Epi Formula" that fell between 15.1 and 58.2 ml/min/1.73 m2 into, group 1 involved cases developing CKD stage 3a, GFR (45-59), group 2 involved cases developing CKD stage 3b, GFR (30-44) and group 3 involved cases developing CKD stage 4, GFR (15-29). Results: TSH exhibited a significant increase within group 3 as opposed to (group 1 and group 2). Anti TPO and anti-thyroglobulin showed an insignificant variation among the three stages of GFR classification and no significant association was seen between GFR and (anti TPO and anti-thyroglobulin). A significant positive association was observed between TSH and (ACR and GFR). Free T3 and free T4 showed an insignificant variation among the three levels of ACR. A significant positive association was also documented between (anti TPO, anti-thyroglobulin) and ACR. No association was observed between GFR and (FT3, FT4, anti TBO, anti-thyroglobulin). Conclusion: In CKD cases of varying etiology but not undergoing hemodialysis, a significant positive association was reported between TSH and (serum urea, creatinine, ACR) and between ACR and (anti TPO and anti-thyroglobulin). A significant negative association was documented between TSH and GFR. | ||
| Keywords | ||
| Thyroid Functions; TSH; CKD; Hypothyroidism; eGFR | ||
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