Relation between Obesity, Insulin Resistance and T2DM: Review Article | ||
| Egyptian Reviews for Medical and Health Sciences | ||
| Article 1, Volume 3, Issue 1, December 2024, Pages 18-27 PDF (294.9 K) | ||
| Document Type: Review article | ||
| DOI: 10.21608/ermhs.2024.333730.1030 | ||
| Authors | ||
| Shorouk Gamal Salah Ibrahim* 1; Abd El-Raouf Mohamed El-Deib2; Sameh Tolba Abu-Elela3; Mohamed Osama Abdalla4; Ahmed Mohammed Mossad5 | ||
| 1Master Degree in internal medicine 2016 (Faculty of Medicine, Suez Canal University), Assistant lecturer of Internal Medicine, (Suez Canal University Hospitals). | ||
| 2Professor of Internal Medicine, Faculty of Medicine, Suez Canal University. | ||
| 3Assistant Professor of General Surgery, Faculty of Medicine, Suez Canal University. | ||
| 4Assistant Professor of clinical pathology, Faculty of Medicine, Suez Canal University. | ||
| 5Lecturer of Internal Medicine, Faculty of Medicine, Suez Canal University. | ||
| Abstract | ||
| Obesity considered as a serious epidemic and one of the leading global causes of preventable deaths. The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing worldwide. There is a strong link between obesity and insulin resistance (IR), as in more than 80 % of patients with obesity develop IR at specific points in their lifetime, which eventually predisposes to metabolic disorders, including metabolic syndrome, prediabetes and T2DM. Sharing powerful genetic and environmental features in their pathogenesis, obesity amplifies the impact of genetic susceptibility and environmental factors on DM. This study aimed to review relation between obesity, insulin resistance and T2DM. Obesity considered as a serious epidemic and one of the leading global causes of preventable deaths. The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing worldwide. There is a strong link between obesity and insulin resistance (IR), as in more than 80 % of patients with obesity develop IR at specific points in their lifetime, which eventually predisposes to metabolic disorders, including metabolic syndrome, prediabetes and T2DM. Sharing powerful genetic and environmental features in their pathogenesis, obesity amplifies the impact of genetic susceptibility and environmental factors on DM. This study aimed to review relation between obesity, insulin resistance and T2DM. | ||
| Keywords | ||
| Body mass index; Diabetes mellites; HOMAIR | ||
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