Synthesis, characterization, antimicrobial activity and DFT studies of novel phthalazine-5,10-dione derivatives | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 08 December 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2024.338104.10845 | ||
| Authors | ||
| Mariam Y. A. Abuderbala1; Mohamed G. El-Banna1; SAMEH A RIZK2; Abeer M. El-Naggar3; A.M.A. Hassan* 1 | ||
| 1Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt. | ||
| 2department of chemistry faculty of science ain shams university | ||
| 3Department of Chemistry, Faculty of Science, Ain Shams University, Abbassiya 11566, Cairo, Egypt | ||
| Abstract | ||
| 1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives (5a-j) were synthesized in good yields using microwave-ultrasonic techniques (MW/US) in an attempt to find possible antibacterial characteristics. They were then described using mass, FTIR, and 1H-NMR spectra data. These antimicrobial compounds were further evaluated against two fungus strains, C. albicans and A. fumigatus, as well as B. subtilis, B. sphaericus, S. aureus (+ ve strains), and P. aeruginosa. Streptomycin is a reference treatment, while amphotericin B is a common antibiotic having antibacterial and antifungal qualities. The antibacterial and antifungal properties of compounds 5b, 5c, 5e, 5i, and 5j were comparable to those of the reference or control molecule. Moreover, to support the energy gap, polarizability, and binding site interactions, a DFT investigation was conducted successively. | ||
| Keywords | ||
| Pyrazolo[1,2-b]phthalazine-5,10-dione; MCRs; Anti-microbial activity; DFT | ||
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