Kadir, A., Pradana, A., Budipramana, K., Ratih, R., Winantari, A. (2024). Combination Quercetin and Poloxamer in a Solid Dispersion Binary System and the Antioxidant Activity Using DPPH and ABTS. test, (), -. doi: 10.21608/ejchem.2024.324927.10589
Abdul Kadir; Aditya Trias Pradana; krisyanti - Budipramana; Ratih - Ratih; Agnes Nuniek Winantari. "Combination Quercetin and Poloxamer in a Solid Dispersion Binary System and the Antioxidant Activity Using DPPH and ABTS". test, , , 2024, -. doi: 10.21608/ejchem.2024.324927.10589
Kadir, A., Pradana, A., Budipramana, K., Ratih, R., Winantari, A. (2024). 'Combination Quercetin and Poloxamer in a Solid Dispersion Binary System and the Antioxidant Activity Using DPPH and ABTS', test, (), pp. -. doi: 10.21608/ejchem.2024.324927.10589
Kadir, A., Pradana, A., Budipramana, K., Ratih, R., Winantari, A. Combination Quercetin and Poloxamer in a Solid Dispersion Binary System and the Antioxidant Activity Using DPPH and ABTS. test, 2024; (): -. doi: 10.21608/ejchem.2024.324927.10589

Combination Quercetin and Poloxamer in a Solid Dispersion Binary System and the Antioxidant Activity Using DPPH and ABTS

Egyptian Journal of Chemistry
Articles in Press, Accepted Manuscript, Available Online from 09 December 2024
Document Type: Original Article
DOI: 10.21608/ejchem.2024.324927.10589
Authors
Abdul Kadir1; Aditya Trias Pradana2; krisyanti - Budipramana* 3; Ratih - Ratih4; Agnes Nuniek Winantari2
1Faculty of Pharmacy, University of Surabaya, Surabaya, 60293 Indonesia
2Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Surabaya 60293, Indonesia
3Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Surabaya
Abstract
Free radicals are unstable and highly reactive chemicals. Free radicals are extremely harmful since they may change the DNA sequence and promote the production of cancer cells, heart disease, Alzheimer's, and inflammatory disorders. Substances such as antioxidants are required to neutralize unstable free radicals such as vitamin C, vitamin E, Q10, and flavonoids like quercetin. The characteristic of quercetin is that it is less soluble in water, which limits the effect of antioxidants. This research aims to investigate the incorporation of poloxamer 188 as a catalyst in solid dispersion and to assess its antioxidant properties through the application of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methodologies. There were 3 types of solid dispersion formulae (F1, F2, and F3) in this study that were observed in their organoleptic and characterized using particle size analyzers (PSA), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR). The results showed that F1 had the highest antioxidant content due to its high presence of poloxamer 188. The IC50 of F1 using DPPH and ABTS was 15.92 ppm and 48.57 ppm, respectively.
Keywords : ABTS; Antioxidants; DPPH; Solid Dispersions; Quercetin
Keywords
ABTS; Antioxidants; DPPH; Solid Dispersions; Quercetin
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