THE ROLE OF PENICILLAMINE AND GREEN TEA ON BRAIN OF ADULT MALE ALBINO RATS AFTER SHORT TERM CHRONIC LEAD EXPOSURE | ||
| Zagazig Journal of Forensic Medicine and Toxicology | ||
| Article 4, Volume 13, Issue 2, July 2015, Pages 49-60 PDF (945.57 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjfm.2015.396531 | ||
| Author | ||
| Abeer Mahmoud* | ||
| Departments of Forensic Medicine and Clinical Toxicology ; Faculty of Medicine; Zagazig University. | ||
| Abstract | ||
| Background: Lead is a highly toxic substance, which can produce a wide range of adverse health effects in adults and children can .The propensity for lead to catalyze oxidative reactions and generate reactive oxygen species has been demonstrated in multiple studies. Aim: The aim of this work was to study the toxic effect of short term chronic lead exposure on lead concentration in blood and oxidative markers in blood. Study the toxic effect of short term chronic lead exposure on brain of adult male albino rats by light and immunohistochmistry. Investigate effect of penicillamine and green tea on these toxicological aspects.Material and Methods: eighty adult male albino rats were used in this study. They were equally divided into eight equal groups, each of ten rats were used. The first group was served as control, the second group was given saline , third group were given penicillamine only, fourth group was given green tea only, and fifth groups were given lead acetate .Six, seven and eight groups were given lead acetate and penicillamine , lead acetate and green tea, lead acetate ,penicillamine and green tea respectively, for one month . Rats of all groups were sacrificed and used for the following parameters: Lead level in blood and oxidative stress parameters in blood. Also histopathological examination of brain tissues by light microscope was done. Results: The results revealed that rats exposed to lead acetate showed significant increasein Glutathione peroxidase and increase in lead levels in blood. The results revealed also pathological changes in the brain tissues .Supplementation with penicillamine alone or green tea alone induced partial reversal of all tested parameters,while in combined adminstration the result was reached nearly the control values .In conclusion: The present study revealed that chronic lead exposure in adult rats induced deleterious effects on brain which reversed partially by supplementation with penicillamine or green tea administration and combined adminstration showed more recovery . It is recommended using antioxidants during treatment of chronic lead poisoning. Also, further studies are needed to evaluate the effec | ||
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