Kamal, N., Aboseidah, A., Osman, M., Desouky, S., Rasmey, A., Said, A. (2024). Impact of Enterococcus Faecalis KY072975 Supplementation as Probiotic on High Cholesterol Level In-vivo. test, 16(2), 405-417. doi: 10.21608/eajbsc.2024.396772
Nehal Kamal; Akram A. Aboseidah; Magdy M. Osman; Salha G. Desouky; Abdel-Hamied M. Rasmey; Alaa F. Said. "Impact of Enterococcus Faecalis KY072975 Supplementation as Probiotic on High Cholesterol Level In-vivo". test, 16, 2, 2024, 405-417. doi: 10.21608/eajbsc.2024.396772
Kamal, N., Aboseidah, A., Osman, M., Desouky, S., Rasmey, A., Said, A. (2024). 'Impact of Enterococcus Faecalis KY072975 Supplementation as Probiotic on High Cholesterol Level In-vivo', test, 16(2), pp. 405-417. doi: 10.21608/eajbsc.2024.396772
Kamal, N., Aboseidah, A., Osman, M., Desouky, S., Rasmey, A., Said, A. Impact of Enterococcus Faecalis KY072975 Supplementation as Probiotic on High Cholesterol Level In-vivo. test, 2024; 16(2): 405-417. doi: 10.21608/eajbsc.2024.396772

Impact of Enterococcus Faecalis KY072975 Supplementation as Probiotic on High Cholesterol Level In-vivo

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Volume 16, Issue 2, December 2024, Pages 405-417    PDF (769.27 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2024.396772
Authors
Nehal Kamal1; Akram A. Aboseidah1; Magdy M. Osman2; Salha G. Desouky1; Abdel-Hamied M. Rasmey1; Alaa F. Said3
1Department of Botany and Microbiology, Faculty of Science, Suez University, Suez 43512, Egypt.
2Dairy Department, Faculty of Agriculture, Suez Canal University, Ismailia 41522, Egypt.
3Agricultural Botany Department, Faculty of Agriculture, Suez Canal University, Ismailia 41522, Egypt.
Abstract
    Elevated blood cholesterol levels are considered a significant and potentially fatal condition in humans. The current study sought to elucidate the effect of the Lactic acid bacteria (LAB) strain Enterococcus faecalisW7 as a probiotic on elevated cholesterol levels in hamsters. Ten male hamsters aged after acclimatization were randomly assigned to the control group (CG) and experimental groups high-fat group (HFG). Hamsters in CG were fed chow pellets only, while those in HFC were fed chow pellets supplemented with 40% beef tallow and 1% cholesterol for 30 days. After achieving obesity, hamsters in HFG were fed the same diet with isolate E. faecalis W7 lypholized powder (390 mg/kg BW/day) with high viable counts of LAB (4 × 1012 CFU/g) orally for two weeks (HFG+E.f. W7). The results demonstrated a significant drop in body weight in the HFG+E.f. W7 group (41.78%) compared to HFG rats (46.82%) and CG rats. The HFG+E.f. W7 group had significantly lower total cholesterol, low denisty lipoprotein (LDL), and triglyceride levels (p<0.05) compared to the HFG and CG groups. The HFG+E.f. W7 group showed substantial decreases (p<0.05) in liver enzymes SGPT and SGOT compared to the HFG and CG groups. While comparing rats in the HFG and CG groups, there was a small drop in HDL levels of 41mg/dL. In conclusion, using E. faecalisW7 per os as a probiotic could be a potential intervention to reverse the adverse effects of excessive cholesterol levels in the blood.
Keywords
Probiotics; Cholesterol; Enterococcus; Bile salt hydrolase (BSH); Hamester
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