MOHAMED, S., SABRY, H., AMER, N., MAHMOUD, S., EL KOMI, W., SELIM, E., ABOUSHOUSHA, T., ATTA, S., SALEH, F., EL-WAKIL, E. (2024). VERIFYING THERAPEUTIC POTENCY OF SHILAJIT AGAINST CRYPTOSPORIDIOSIS: AN EXPERIMENTAL STUDY. test, 54(3), 447-452. doi: 10.21608/jesp.2024.397260
SHAIMAA S. MOHAMED; HODA Y. SABRY; NEIMAT M. AMER; SOHEIR S. MAHMOUD; WAFAA EL KOMI; EMAN H. SELIM; TAREK ABOUSHOUSHA; SHIMAA A. ATTA; FATMA EL-ZAHRAA R. SALEH; EMAN S. EL-WAKIL. "VERIFYING THERAPEUTIC POTENCY OF SHILAJIT AGAINST CRYPTOSPORIDIOSIS: AN EXPERIMENTAL STUDY". test, 54, 3, 2024, 447-452. doi: 10.21608/jesp.2024.397260
MOHAMED, S., SABRY, H., AMER, N., MAHMOUD, S., EL KOMI, W., SELIM, E., ABOUSHOUSHA, T., ATTA, S., SALEH, F., EL-WAKIL, E. (2024). 'VERIFYING THERAPEUTIC POTENCY OF SHILAJIT AGAINST CRYPTOSPORIDIOSIS: AN EXPERIMENTAL STUDY', test, 54(3), pp. 447-452. doi: 10.21608/jesp.2024.397260
MOHAMED, S., SABRY, H., AMER, N., MAHMOUD, S., EL KOMI, W., SELIM, E., ABOUSHOUSHA, T., ATTA, S., SALEH, F., EL-WAKIL, E. VERIFYING THERAPEUTIC POTENCY OF SHILAJIT AGAINST CRYPTOSPORIDIOSIS: AN EXPERIMENTAL STUDY. test, 2024; 54(3): 447-452. doi: 10.21608/jesp.2024.397260

VERIFYING THERAPEUTIC POTENCY OF SHILAJIT AGAINST CRYPTOSPORIDIOSIS: AN EXPERIMENTAL STUDY

Journal of the Egyptian Society of Parasitology
Article 13, Volume 54, Issue 3, December 2024, Pages 447-452    PDF (3.67 M)
Document Type: Original Article
DOI: 10.21608/jesp.2024.397260
Authors
SHAIMAA S. MOHAMED1; HODA Y. SABRY1; NEIMAT M. AMER1; SOHEIR S. MAHMOUD1; WAFAA EL KOMI1; EMAN H. SELIM1; TAREK ABOUSHOUSHA2; SHIMAA A. ATTA3; FATMA EL-ZAHRAA R. SALEH4; EMAN S. EL-WAKIL1
1Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt
2Department of Pathology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt
3Department of Immu nology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt
4Department of Water Pollution Research, Environmental and Climate Change Institute, National Research Centre (NRC), Egypt
Abstract
In immunocompromised hosts, diarrheal disease is primarily caused by Cryptosporidium spp. 
infect-ion. Up- to-date, there is neither vaccine nor safe or efficient treatment. Shilajit is one the 
medicinal plants. This study evaluated Shilajit anti-cryptosporidiosis alone or with Nitazoxanide® 
(NTZ) in immunocompromised Albino mice. The study comprised fifty mice divided into five gr
oups of ten mice each.  The oocysts shedding were assessed parasitologically by stained fecal 
smears, histologically in liver and small intestine, and immunologically by evaluation of IFN-γ 
and IL-10 levels. 
The results showed that shilajit improved the liver and small intestine significantly by oocysts 
reduction in feces and small intestine. Mice treated with both shilajit and NTZ showed the best 
improvement. IFN-γ increased and IL-10 decreased (P< 0.001) in all treated mice. 
Keywords
Cryptosporidium parvum; Shilajit; Nitazoxanide; Immunocompromised mice
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