MATAR, A., FAHMY, Z., ABDELHAMEED, R., SHENDI, S. (2024). ANTIPARASITIC AND IMMUNOLOGICAL EFFECTS OF SPIRULINA OR PROBIOTICS LOADED ON METAL ORGANIC FRAMEWORK (MOFS) NANO PARTICLES IN MICE INFECTED WITH CRYPTOSPORIDIUM. test, 54(3), 459-467. doi: 10.21608/jesp.2024.397262
AMIRA M. MATAR; ZEINAB H. FAHMY; REDA M. ABDELHAMEED; SAWSAN S. SHENDI. "ANTIPARASITIC AND IMMUNOLOGICAL EFFECTS OF SPIRULINA OR PROBIOTICS LOADED ON METAL ORGANIC FRAMEWORK (MOFS) NANO PARTICLES IN MICE INFECTED WITH CRYPTOSPORIDIUM". test, 54, 3, 2024, 459-467. doi: 10.21608/jesp.2024.397262
MATAR, A., FAHMY, Z., ABDELHAMEED, R., SHENDI, S. (2024). 'ANTIPARASITIC AND IMMUNOLOGICAL EFFECTS OF SPIRULINA OR PROBIOTICS LOADED ON METAL ORGANIC FRAMEWORK (MOFS) NANO PARTICLES IN MICE INFECTED WITH CRYPTOSPORIDIUM', test, 54(3), pp. 459-467. doi: 10.21608/jesp.2024.397262
MATAR, A., FAHMY, Z., ABDELHAMEED, R., SHENDI, S. ANTIPARASITIC AND IMMUNOLOGICAL EFFECTS OF SPIRULINA OR PROBIOTICS LOADED ON METAL ORGANIC FRAMEWORK (MOFS) NANO PARTICLES IN MICE INFECTED WITH CRYPTOSPORIDIUM. test, 2024; 54(3): 459-467. doi: 10.21608/jesp.2024.397262

ANTIPARASITIC AND IMMUNOLOGICAL EFFECTS OF SPIRULINA OR PROBIOTICS LOADED ON METAL ORGANIC FRAMEWORK (MOFS) NANO PARTICLES IN MICE INFECTED WITH CRYPTOSPORIDIUM

Journal of the Egyptian Society of Parasitology
Article 15, Volume 54, Issue 3, December 2024, Pages 459-467    PDF (5.65 M)
Document Type: Original Article
DOI: 10.21608/jesp.2024.397262
Authors
AMIRA M. MATAR1; ZEINAB H. FAHMY2; REDA M. ABDELHAMEED3; SAWSAN S. SHENDI4
1Department of Medical Parasitology, Faculty of Medicine, Menoufia University, Egypt
2Department of Immunology and Drug Evaluation, Theodor Bilharz Research Institute (TBRI), Imbaba, Egypt
3Department of Applied Organic Chemistry, Chemical Industries Research Institute, National Research Centre, Dokki, Giza, Egypt
4Department of Clinical and Molecular Parasitology, National Liver Institute, Menoufia University, Menoufia Governorate, Egypt
Abstract
One of the zoonotic health problem affecting is cryptosporidiosis. There is currently no 
approved treatment for cryptosporidiosis, apart from nitazoxanide (NTZ). This study evaluated 
the anti-protozoan and immune-modulating properties role of spirulina and probiotics, either 
alone or loaded on Cu-MOF, against Cryptosporidium in immunocompromised mice compared 
to NTZ. Seventy-eight male laboratory-bred pathogen-free, Swiss-albino mice were divided 
into seven groups each of 12 mice except negative control one with six mice as follows: GI: 
infected-untreated (positive control), GII: infected and Spirulina treated, GIII: infected and 
probiotics treated, GIV: infected and NTZ treated, GV: infected and Spirulina loaded on Cu
BTC MOF treated, GVI: infected and probiotics loaded on Cu-BTC MOF treated, GVII: 
neither  infected nor treated (negative control). Drug efficacy was parasitological, biochemical 
and histopathological evaluated.  
The results showed that all drugs significantly reduced oocysts' count and intestinal parasite 
burden as well as improved pathological squeals compared to corresponding infected mice. 
There was a decrease in amyloid and neopterin sera levels in treated mice compared to infected 
ones. NTZ gave the best treated results, followed by Spirulina nano formulation. 
Keywords
Cryptosporidiosis; Mice; NTZ; Cu-BTC MOF; SAA; Neopterin
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