VITAMIN (E) PROTECTIVE ROLE AGAINST ROUNDUP TESTICULAR GENOTOXICITY IN MALE RATS | ||
| The Egyptian Journal of Forensic Sciences and Applied Toxicology | ||
| Article 1, Volume 16, Issue 1, June 2016, Pages 1-10 PDF (630.22 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejfsat.2016.39947 | ||
| Authors | ||
| Samah F. Ibrahim1; Mona M. Ali1; Heba El Malt2; Manal Ewaiss3 | ||
| 1Lecturer of forensic medicine and clinical toxicology- Kasr Alaini- Cairo University | ||
| 2Lecturer of medical biochemistry and molecular biology, National Research Center | ||
| 3Lecturer of medical biochemistry and molecular biology .faculty of medicine, Beni sueif universty | ||
| Abstract | ||
| Round up, a worldwide herbicide has cellular and genotoxic effects. Round up’s genotoxicity was tested by detecting the expression of the steroidogenic acute regulatory, aromatase, estrogen and androgen receptor genes in testicular cells. Its cytotoxicity was examined by measuring caspase 3 gene expressions. Genes’ expressions were assessed by RT- PCR. Testicular lesions were detected by histopathological examination. We determined the role of vitamin E in reducing its toxic effects. Our study determined that Round up toxic doses caused endocrinal disruption through alteration of genes expression and effects on cellular integrity by increasing apoptosis. Administration of the vitamin E during exposure can reduce and protect against these endocrine cytogenotoxic effects. | ||
| Keywords | ||
| Round up; genotoxicity; testicular; RT-PCR and Vit E | ||
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