Nanosized Aluminum Metal-Organic Framework Encapsulating Edaravone Drug: Synthesis and Characterization. | ||
| Assiut University Journal of Multidisciplinary Scientific Research | ||
| Volume 54, Issue 1, January 2025, Pages 130-142 PDF (395.27 K) | ||
| Document Type: Novel Research Articles | ||
| DOI: 10.21608/aunj.2024.329999.1097 | ||
| Authors | ||
| rabab mohamed osman* 1; A. Abu El-Fadl2; Abdelhamid Darwish; Ahmed Sayed3 | ||
| 1Physics, faculty of science, Assiut university, Assiut | ||
| 2Assuit University, faculty of Science,departement of Physics | ||
| 3Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt | ||
| Abstract | ||
| The hydro solvothermal method was employed to synthesize nano porous aluminum metal organic framework (Al-MOF) nanoparticles (NPs), which were utilized as a matrix for the pharmaceutical delivery of Edaravone (Ed). The drug encapsulation efficiency (EE) and loading capacity (LC) indicate the potential of Al metal organic framework NPs as effective drug delivery vehicles. The structural and functional properties of both the Al metal organic framework NPs and Ed-loaded Al metal organic framework NPs (Ed@Al-MOF) were characterized using several techniques, including ultraviolet-visible (UV-Vis) spectroscopy, Transmission Electron Microscopy (TEM) for morphological analysis, X-ray diffractometry (XRD), and Fourier-transform infrared (FTIR) spectroscopy. Additionally, the thermal stability of the Ed@Al metal organic framework NPs was evaluated through thermogravimetric analysis (TGA). These promising results underscore the potential of Al metal organic framework NPs as a viable platform for drug delivery, necessitating further investigations to confirm the applicability of Ed@Al metal organic framework NPs in therapeutic contexts. | ||
| Keywords | ||
| UV-VIS; EE; LC; TEM; FTIR | ||
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