Correlation Between Serum Apoptotic Markers and Hepatitis C viral load In Chronic Hepatitis C Virus-Related Liver Disease | ||
| Sohag Medical Journal | ||
| Article 7, Volume 21, Issue 1, January 2017, Pages 65-76 PDF (138.47 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/smj.2017.40006 | ||
| Author | ||
| Eman Sabet | ||
| Department of Internal medicine ; Faculty of medicine; Sohag University. | ||
| Abstract | ||
| Hepatitis C virus (HCV) is considered the most common etiology of chronic liver disease in Egypt. Developing non invasive tests that can predict liver injury represents a growing medical need. Considering that hepatocyte apoptosis plays a role in chronic hepatitis C pathogenesis; evaluation of the presence of different apoptotic markers that correlate with liver injury in HCV- related liver diseases could be a way for this achievement. The aim of the present study was to identify the correlation between serum apoptotic markers Bcl-2 and Bax with hepatitis C viral load in the chronic hepatitis C virus related liver diseases. The study included three groups ; group 1: 35 compensated chronic HCV patients without any suspected evidence of liver cirrhosis and with Child - Pugh score of 5-6 (class A), Group 2: 35 decompensated chronic HCV patients with Child - Pugh score of 10-15 (class C) and group 3: 15 healthy volunteers as a control group. The results collectively suggest that statistically significant correlations were noticed between serum Bcl-2, Bax, Bcl-2/Bax ratio and HCV PCR in chronic hepatitis C virus-related liver disease. | ||
| Keywords | ||
| Chronic HCV; Hepatitis; Bcl-2; Bax | ||
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| References | ||
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