IMMUNE RESPONSE OF VEAL CALVES TO BVDV VACCINATED WITH PNEUMOVAC PLUS VACCINE IN EGYPT | ||
| Egyptian Journal of Agricultural Research | ||
| Article 23, Volume 75, Issue 1, March 1997, Pages 273-281 PDF (1.93 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejar.1997.403234 | ||
| Authors | ||
| THANAA I. BAZ1; MOHAMED E. SHAWKAT2; HUSSIEN M. MOHAMED1; MAGDY M. EL-SABBAG1; SAMIRA S. TAHA1 | ||
| 1Serum and Vaccine Research Institute, Agricultural Research Centre, Giza, Egypt | ||
| 2Faculty of Veterinary Medicine, Cairo University, Giza, Egypt | ||
| Abstract | ||
| Forty veal calves were used in the study; thirty calves were vaccinated and 10 rest were used as control. The vaccine dose was by two injections I/M 2 weeks apart. Eighteen of the vaccinated calves developed BVD serum neutralizing (SN) antibodies at 21 or 28 days, where 6 of them responded in low non-protective titre that was lost quickly at 1.5 - 2 months post-vaccination (PV). The rest 12 calves developed a protective SN titre that lasted for 4 months or less PV (40 %). Twelve vaccinated calves did not respond for vaccination and no SN BVD antibodies were detected. Bovine virus diarrhoea virus infection and isolation were recorded in 5 non-vaccinated calves; 3 of them did not develop BVD antibodies. Also, BVD virus infection was recorded in vaccinated calves, but in 3 of those which lost their protection BVD titre. BVD immune suppression was detected in vaccinated calves which did not respond to vaccination (60 %, comprising 12 calves that did not respond and 6 responded weakly to BVD vaccination). Also, the study proved immune tolerance to BVD in 3 non-vaccinated calves which got BVD infection without development of any SN BVD antibodies. The study declared that the vaccine is satisfactory to protect immune competent veal calves from BVD infection. Also, the study proved immune tolerance of calves to BVD, a problem necessitating study to control. | ||
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