Role of Recent MRI Technique (Double Inversion Recovery Sequence) in Diagnosis of Multiple Sclerosis Disease | ||
| SVU-International Journal of Medical Sciences | ||
| Article 86, Volume 7, Issue 2, July 2024, Pages 995-1007 PDF (763.26 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2024.262335.1783 | ||
| Authors | ||
| Ghada Mohamd Abd Elrazik1; Anfal Mohamed Taha* 1; Mahmoud Mohamed Abd Elhamed Abo Elhafiz2; Abdalraheem Huessin Ali1 | ||
| 1Diagnostic and Interventional Radiology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| 2Neuropsychiatry Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| Abstract | ||
| Background: Multiple sclerosis causes neurological impairment in middle-aged and young people. The McDonald criteria help diagnose, whereas T2-weighted and FLAIR MRI are essential for monitoring. The Double Inversion Recovery (DIR) sequence reduces CSF fluid improving diagnostic contrast. Objectives: To evaluate the role of DIR sequence in detecting brain lesions in MS patients compared to FLAIR and T2 sequences. Patients and methods: This prospective research at Qena University Hospital examined 100 confirmed MS patients referred from the neurology department diagnostic criteria. The Radiology Department performed extensive assessments, medical history gathering, physical exams, and brain MRI scans with specified sequences (T1-weighted, T2-weighted, FLAIR, DIR). Anatomically classified lesions were utilized to examine MRI effectiveness for MS diagnosis and DIR sequence usefulness compared to FLAIR and T2 sequences. Results: Patients, mean age 35±9.66years, with a mean sickness duration of 40.05±53.25months, were mostly women (91%). Remission occurred in 83%, secondary progression in 12%, and primary progressive in 5%. The mean EDSS score was 3.65, indicating moderate to severe impairment. DIR detected more lesions than T2, especially cortical lesions(9.37±8.9). Disease duration correlated positively with DIR and FLAIR. EDSS significantly correlated positively with lesions across all MRI. Conclusion: DIR augments conventional MRI for early MS lesion detection, particularly in shorter illness durations. DIR detects overall and cortical lesions better than T2 and FLAIR. The remarkable correlation between EDSS scores and lesion counts across all MRI modalities shows their clinical relevance in disease severity assessment. | ||
| Keywords | ||
| Double Inversion Recovery sequence; Diagnosis, Multiple Sclerosis | ||
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