Pleiotropic Effect of Statins: Beyond Cholesterol Reduction | ||
| Octahedron Drug Research | ||
| Article 4, Volume 6, Issue 1, January 2025, Pages 40-49 PDF (678.57 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/odr.2025.347446.1046 | ||
| Author | ||
| Abdelrahman Awad Zarief* | ||
| Medicinal Chemistry, Faculty of Pharmacy, Portsaid University, Portsaid, Egypt | ||
| Abstract | ||
| Although statins are best known for their ability to decrease cholesterol, they are now known to be complex pharmacological agents with a variety of pleiotropic effects. This review looks at the strong evidence that statins have pleiotropic effects in addition to their well-known ability to decrease cholesterol levels in blood. We explore the molecular processes that underlie these pleiotropic effects, such as the regulation of oxidative stress and thrombosis, stabilization of atherosclerotic plaques, enhancement of endothelial function, and modulation of inflammatory pathways. We also investigate the possible therapeutic applications of statin pleiotropy in a range of disease states, such as cancer, autoimmune illnesses, neurodegenerative disorders, and cardiovascular disease. The present review provides a thorough overview of the complex and multifaceted character of statins, even though the precise therapeutic implications of several pleiotropic effects is still being investigated, demonstrating their potential to go beyond conventional methods for reducing cardiovascular diseases risk. | ||
| Keywords | ||
| HMG-CoA reductase inhibitor; cholesterol; atherosclerotic plaques; inflammation | ||
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