Effect of Fenugreek (Trigonella foenum-graecum) seed extract and glibenclamide in albino rats with diabetic | ||
| Egyptian Journal of Food Science | ||
| Articles in Press, Accepted Manuscript, Available Online from 21 January 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejfs.2025.323936.1197 | ||
| Authors | ||
| Nesrein Salim* ; Mohamed Abdelalim | ||
| Department of Biochemistry, Faculty of Agriculture, Benha University | ||
| Abstract | ||
| TTrigonella foenum is using for therapeutic purposes in different cultures, which has an antidiabetic effect by reducing blood sugar concentrations. This work is aimed to determine the properties of antioxidant and poly phenol content of ethanolic fenugreek (Trigonella foenum-graecum) seed extract (FSE). Additionally, glibenclamide, a common medication, was contrasted with the antihyperglycemic Wister albino rats. Total flavonoid and total phenolic contents in FSE (mg g−1) accounted for 126.50 as QE and 325.07 as GAE; respectively whereas DPPH and ABTS (83.11 and 72%) were used to measure antioxidant activity. Six phenolic and five-flavonoid component were found in the FSE after examined using HPLC. Thirty rats were split up into five groups for the in vivo experiment. Group 1 was the normal control, whereas diabetic rats (caused by a single 100 mg kg-1 b.w. alloxan dose) were found in Group 2. Group three contained diabetic rats that received an oral dose of 10 mg kg-1 of glibenclamide. Group four contained diabetic rats orally administrated with 100 mg kg−1 FSE daily. Group 5 received an oral dose of with 200 mg kg−1 FSE. The study had 56 days. Administration of both dosages (100 and 200 mg kg-1) with FSE diabetic rats significantly reduced blood glucose, total lipid, total cholesterol and LDL levels in diabetic rats, as well as increasing levels of high density lipoprotein cholesterol and enhancing kidney and liver functions. | ||
| Keywords | ||
| DPPH; diabetes; fenugreek extract | ||
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