Mitigating Physiological and Histological Changes Induced by a High-Salt Diet in Male Albino Rats Using Origanum majorana and Olea europaea Leaf Extracts | ||
| Animal Physiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 22 January 2025 PDF (1.15 M) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/apj.2025.347045.1000 | ||
| Author | ||
| Mohamed Gaber Shaalan* | ||
| Zoology and Entomology Department, Faculty of Science, Arish University, Arish, Egypt. | ||
| Abstract | ||
| This research explored the possible protective impact of marjoram and olive leaf extracts against hypertension triggered by a salt-rich diet in rats. Twenty male albino rats (Rattus norvegicus) were separated into four equal groups; the first group was the reference control, and the second group was provided 250 mg/Kg body weight of Origanum majorana leaves extract and 250 mg/Kg body weight of Olea europaea leaves extract daily. The third group was given freely a high 8% NaCl diet. The fourth group was administered an 8% salt diet supplemented with 250 mg/Kg body weight of O. majorana leaves extract and 250 mg/Kg body weight of O. europaea leaves extract. Samples were taken after 4 weeks of treatments. Feeding rats, a high sodium chloride diet consisting of 8% NaCl induces hypertension in rats. The high salt diet enhanced marked elevation in body weights and reduced most relative organ weights. The high salt feeding elevated sodium levels in hepatic and kidney tissues, in addition to a rise in the liver's MDA level. Feeding on a high salt diet reduced superoxide dismutase and catalase activities. It promoted considerable disruption in liver and kidney functions. It also triggered a decrease in sperm count and an increase in abnormal sperm morphology. The high salt feeding induced histological changes in the liver, kidney, brain, and testes of rats. Combined supplementation with both O. majorana and O. europaea extracts alleviated salt-induced abnormalities in rats. | ||
| Keywords | ||
| Marjoram; Olive; Sodium Chloride; Oxidative stress; Histological alterations | ||
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