Synthesis, Enantio-Separation and Molecular Docking Study of Hesperidin-Oxime | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 5, May 2025, Pages 401-408 PDF (1.01 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2025.333625.10739 | ||
| Authors | ||
| Meriem BOUANINI; Nasser Belboukhari* ; Khaled Sekkoum; Djawhara Haddad | ||
| univ TM Bechar, Fac sciences exactes, bechar PO 417 Bechar, Algerie | ||
| Abstract | ||
| This study aims to synthesize hesperidin oxime from hesperidin, chiral separation by HPLC method and comparative study of two enantiomers as anti-inflammatory agents by docking them with Proto-oncogene serine/threonine-protein kinase Pim-1 using MOE software (4.2). The structure of the synthesized product was validated through UV, IR,1H-NMR, and13C-NMR spectroscopic techniques. Hesperidin-oxime was separated chirally in normal phase mode employing polysaccharide-based chiral stationary phases, namely Chiralcel® OD-H, Chiralcel® OD-RH, and CHIRALPAK® AD-3R, under both normal and polar organic phase modes. Molecular docking shows that S- hesperidin oxime gave better binding affinity towards pim-1 compared to R- hesperidin oxime. | ||
| Keywords | ||
| Hesperidin oxime; HPLC; molecular docking; Pim-1; anti-inflammatory | ||
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