Neutrophil to Lymphocyte Ratio and Interleukin-6 Level in Evaluation of Inflammation in Chronic Hemodialysis Patients with and without Residual Kidney Functions | ||
| Medicine Updates | ||
| Volume 22, Issue 22, July 2025, Pages 1-11 PDF (856.42 K) | ||
| Document Type: Research project | ||
| DOI: 10.21608/muj.2025.350949.1200 | ||
| Authors | ||
| Noha A Mustafa* 1; Mamdouh El Nahas2; Basma Badreldin3; Hanzada Elmaghrabi4; Ahmed Samir Megahed4 | ||
| 1Internal medicine,faculty of medicine, portsaid university, portsaid, Egypt | ||
| 2prof of internal medicine port said university | ||
| 3Faulty of medicine Port said university | ||
| 4Lecturer of nephrology, internal medicine department, faculty of medicine, portsaid university, Egypt | ||
| Abstract | ||
| Background: Chronic inflammation is a main characteristic of chronic kidney disease (CKD) and is exacerbated in patients undergoing hemodialysis (HD). Residual kidney function (RKF) plays a vital role in mitigating inflammation. We aimed to assess the utility of neutrophil-to-lymphocyte ratio (NLR) and interleukin-6 (IL-6) as inflammatory markers in HD cases with and without RKF. Methods: A cross-sectional study was conducted on 100 CKD cases on HD, categorized into two groups based on RKF presence. NLR and IL-6 levels were measured and analyzed in relation to demographic, clinical, and biochemical parameters. Statistical analysis included correlation studies and receiver operating characteristic (ROC) curve analysis. Results: IL-6 levels and NLR were significantly increased in cases without RKF (p < 0.05). ROC analysis revealed IL-6 as a better marker for predicting loss of RKF compared to NLR. Correlations were observed between IL-6 levels, inflammatory markers, and renal parameters. Conclusions: IL-6 and NLR are useful biomarkers for assessing inflammation in HD patients, with IL-6 demonstrating superior predictive value for RKF status. Monitoring these markers can provide insights into inflammation management in CKD. | ||
| Keywords | ||
| CKD; Hemodialysis; Residual kidney function; Interleukin-6; Neutrophil-to-lymphocyte ratio | ||
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