Predictive Factors for Site of Local and Systemic Recurrence in Breast Cancer Patients | ||
| SECI Oncology Journal | ||
| Volume 13, Issue 1, January 2025, Pages 15-23 | ||
| Abstract | ||
| Background and aim of the work: Breast cancer is the most common type of female cancer in Egypt with high morbidity and mortality. The purpose of this study is to assess whether clinical characteristics can predict the most probable site of recurrence Methods: We retrospectively studied clinic-pathological characteristics of 134 female patients had breast cancer who presented at South Egypt Cancer Institute (SECI) from January 2015 to December 2022 for association with certain metastatic sites. Results: Our data analysis revealed that premenopausal status, low Body Mass Index (BMI) and high Ki67 can predict higher incidence of bone metastasis. Nodal involvement and Progesterone Receptor (PR) negativity can predict higher incidence of lung metastasis. Age younger than 50 years, premenopausal status and presence of Ductal Carcinoma in Situ (DCIS) component can predict higher incidence of liver metastasis. Tumor size ≥T3 can predict higher incidence of brain metastasis. Lastly, larger tumor size ≥ T3, low BMI, ER negativity, PR negativity and high Ki67 can predict higher chance for recurrence. Grade III differentiation and PR negativity led to increase of lymph node metastasis. Conclusion: Certain clinicopathological characteristics are associated with specific sites of metastasis, which direct health care providers for meticulous follow up. | ||
| Keywords | ||
| breast cancer; recurrence; metastasis; South Egypt Cancer Institute | ||
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