Elwakil, O., Hamed, W., Nada, O., Badran, E. (2025). A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis. test, 24(2), 141-151. doi: 10.21608/epj.2025.407379
Omar R. Elwakil; Waleed A. Hamed; Ola H. Nada; Ethar M. Badran. "A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis". test, 24, 2, 2025, 141-151. doi: 10.21608/epj.2025.407379
Elwakil, O., Hamed, W., Nada, O., Badran, E. (2025). 'A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis', test, 24(2), pp. 141-151. doi: 10.21608/epj.2025.407379
Elwakil, O., Hamed, W., Nada, O., Badran, E. A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis. test, 2025; 24(2): 141-151. doi: 10.21608/epj.2025.407379

A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis

Egyptian Pharmaceutical Journal
Article 1, Volume 24, Issue 2, April 2025, Pages 141-151    PDF (3.48 M)
DOI: 10.21608/epj.2025.407379
Authors
Omar R. Elwakil1; Waleed A. Hamed1; Ola H. Nada2; Ethar M. Badran1
1Department of aTropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Department of bPathology,Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background
Ulcerative colitis(UC)isatypeofchronicinflammatoryboweldiseaseinthecolon
thatisstillofunknownaetiology.What is known, till now,isthatUCisconfinedtothe
colonstartingattherectumandextendingproximallyforavariabledistancetill
reaching the cecum,anddespiteUCisknowntohavevariousextracolonic
presentations,theuppergastrointestinaltract(UGIT)isnotgenerallyconsidered
as target organ.
Aim
ThecurrentstudyaimedtodescribeUGITclinical, endoscopic, and
histopathologicalfindingsinadultEgyptianpatientswithUC.
Patients and methods
Thestudywasconductedon56UCpatients.IntheTropicalMedicineDepartment
Faculty of Medicine, AinShamsUniversity.Allthepatientsweresubjectedtofull
historytakingandthoroughclinicalexamination.UGITendoscopywasperformed
onallpatientstostudytheendoscopicfindingsintheoesophagus, stomach, and
duodenumandtotakebiopsiesforhistopathologicalexamination.
Results
Thecurrentstudyhasshownthat60.7%ofpatientshadgastroesophagealreflux
diseaseuponesophagogastroduodenoscopywhilemicroscopicevaluationof
oesophagealbiopsiesshowedthat50%ofthecaseswerehavingesophagitis.
Regardinggastroduodenalaffection, UGITendoscopyrevealedthat91.1%ofthe
patientshadgastritisand78.6%hadduodenitis, histopathological examination of
thebiopsysamplesrevealedthat53.6%ofthecaseshadchronicnonspecific
gastritis,33.9%ofthecasesshowedchronicgastritiswithhelicobacterpylori
infectionand85.7%hadchronicnonspecificduodenitis.The present study
showedthatUGITaffectionwasdiagnosedcollectivelyin96.4and87.5%ofthe
casesbyendoscopyandbiopsy, respectively.
Conclusion
ThecurrentstudyhasprovedtheassociationbetweenUCandthepresenceof
endoscopic findings in the esophagus, stomach, and duodenum.These findings
wereconfirmedbyhistopathologicalexaminationofmucosalbiopsiestakenfrom
the esophagus, stomach, and duodenum.
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