Recent Advances in 2(3H)-Furanone Chemistry and Its Hydrazide Derivative: Synthesis and Reactions | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 27 January 2025 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2025.329442.10665 | ||
| Authors | ||
| Hend Medhat El-Shanbaky* 1; rania Helmy abdelhameed2; Mosaad Sayed Mohamed1; Samar Said Fatahala3 | ||
| 1Pharmaceutical organic chemistry department, Faculty of Pharmacy, Helwan University, Cairo, Egypt | ||
| 2Pharmaceutical Organic Chemistry Department, faculty of pharmacy, Helwan University | ||
| 3Pharmaceutical Organic Chemistry Department, Faculty of pharmacy, Helwan University | ||
| Abstract | ||
| The 2(3H)-furanones and their hydrazide derivatives have a wide spectrum of biological activities, including anti-inflammatory, analgesic, antibacterial, antiviral, anticonvulsant, and anticancer properties. They are an important starting material for synthesis of numerous pyrrolone, pyridazinone, and imidazole derivatives. For these reasons, together with our interest in furanone chemistry, we decided to conduct a systematic study of contemporary synthesis and reactions from 2019 to 2023, with a special emphasis on the 3-arylidene-2(3H)-furanones. New furanones and hydrazides can be synthesized and utilized to obtain other heterocyclic compounds to identify their biological applications. | ||
| Keywords | ||
| Furanone; Hydrazide; Pyridazinone; Pyrrolone; Butanoic acid; γ-lactones | ||
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