Histological and Immunohistochemical changes induced by exposure to different doses of silver nanoparticles in Liver and Lungs of adult Albino rat | ||
| SVU-International Journal of Medical Sciences | ||
| Volume 8, Issue 1, January 2025, Pages 170-184 PDF (3 M) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2025.345727.2054 | ||
| Authors | ||
| Dina Mohammed Salah; Abeer Fareed Abd El-Naeem* ; Zahraa Mohamed Ismael | ||
| Human Anatomy & Embryology Department, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| Abstract | ||
| Background: Nowadays there are varied manipulations of the silver nanoparticles (AgNPs) in educative and manufacturing topics; they are employed in surgical implements, orthopedic equipment, tools of family planning and catheters. They are also handled in drug conveyance, antiviral, germicidal and anticancer mediators. Objectives: Study the changes that occurred due todifferent dosages of silver nanoparticles in the liver and lungs of adult albino rats. Materials and methods: Silver nanoparticle solution was consumed. A total of 30 adult male albino rats were alienated to three equivalent groups; group I (control): divided into 2 subgroups, negative and positive with 5 rats each, group II (AgNPs low dose) which was intraperitoneally injected with AgNPs in a dose of 2 mg/kg once daily for 4 weeks, group III ( AgNPs high dose): rats were injected intraperitoneally with AgNPs in a dose of 4 mg/kg body weight once daily for 4 weeks. 24 hours after the last dose, rats were anesthetized and dissected, where the lungs and livers were taken and prepared for hematoxylin and eosin (H&E) and immunohistochemical study. Results: Histological and immunohistochemical investigations showed the destructive and inflammatory effects of low dose of silver nanoparticle in the liver and lung tissues of adult rats and in larger doses these toxic effects were more extensive. Conclusion: The toxicity of silver nanoparticles caused dose-related deteriorating alterations in the liver and lung tissues. | ||
| Keywords | ||
| AgNPs; TNF-α; Liver; Lung | ||
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