Bioactive lignans and other phenolics from the roots, leaves and seeds of L. grown in Egypt | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 11, Issue 1, June 2012, Pages 59-65 PDF (467.62 K) | ||
| DOI: 10.7123/01.EPJ.0000415466.17860.6a | ||
| Authors | ||
| Elsayed A. Aboutabl; Mona E. El Mahdy; Nadia M. Sokkar; Amany A. Sleem; Manal M. Shams | ||
| Abstract | ||
| Aim Investigation of the phenolic constituents of roots, leaves and seeds of L. cultivated in Egypt. Methods Qualitative and quantitative analysis of lignans and other phenolics by LC-MS/MS and HPLC/PDA-LC-MS/MS, as well as evaluation of potential bioactivities. Results and conclusions LC-MS/MS of the ethyl acetate fractions from seeds, leaves and roots showed the presence of 13 phenolics, including lignans, distributed in the different organs. The following phenolics were identified: caffeic acid , genistein , biochanin A , luteolin , chlorogenic acid , materisenol , arctigenin , quercetin , cynarin , arctiin , lappaol A , rutin and lappaol F . Quantification of these compounds by HPLC-PDA-MS/MS showed that arctiin was the major compound in seeds. The antioxidant, antihepatotoxic, anti-inflammatory and cytotoxic activities of ethanolic extracts of the different organs were evaluated. | ||
| Keywords | ||
| antihepatotoxicity; Anti-inflammatory; antioxidant; L; Coumarin; Cytotoxicity; lignans; Phenolics | ||
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